{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:21:33Z","timestamp":1761704493729,"version":"build-2065373602"},"reference-count":0,"publisher":"CSIRO Publishing","issue":"4","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":12961,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,12,1]]},"abstract":"<jats:p>Androgen binding activity, indistinguishable from sex-hormone-binding globulin (SHBG) in serum, has been identified in human follicular fluid by binding analyses (saturation and Scatchard analyses and binding specificity), immunoradiometric assay and Con-A Sepharose chromatography. Follicular fluid was obtained at the time of oocyte recovery from either individual follicles (range 2-7) from seven patients, or as a pool obtained from follicles of several patients who had received a Clomid-human menopausal gonadotrophin treatment to stimulate follicular growth as part of an in vitro fertilization program. Concentrations of SHBG in follicular fluid varied between individual follicles (750 +\/- 202 fmol mg-1 protein; mean +\/- s.d.; n = 14) and ranged above and below concentrations of SHBG in serum (948 +\/- 171 fmol mg-1 protein; n = 5) taken 4 h before oocyte recovery and harvest of follicular fluid. There were strong correlations (r = 0.7-0.9) between the steroid and SHBG contents in individual follicular fluids of two patients. However, the concentration of SHBG in follicular fluid was generally 100-fold lower than that of oestradiol or progesterone, suggesting that SHBG may play some role other than determining the concentration of unbound steroid in the follicle.<\/jats:p>","DOI":"10.1071\/rd9890289","type":"journal-article","created":{"date-parts":[[2005,10,18]],"date-time":"2005-10-18T21:17:15Z","timestamp":1129670235000},"page":"289-297","source":"Crossref","is-referenced-by-count":3,"title":["Sex-hormone-binding globulin in human follicular fluid and serum at the time of oocyte recovery"],"prefix":"10.1071","volume":"1","author":[{"given":"SM","family":"Campo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PA","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JK","family":"Findlay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/1\/4\/289\/297630\/rd9890289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/1\/4\/289\/297630\/rd9890289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:58:08Z","timestamp":1761688688000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/1\/4\/289\/47764\/Sex-hormone-binding-globulin-in-human-follicular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,12,1]]}},"URL":"https:\/\/doi.org\/10.1071\/rd9890289","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"type":"print","value":"1031-3613"},{"type":"electronic","value":"1448-5990"}],"subject":[],"published":{"date-parts":[[1989,12,1]]}}}