{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T04:01:49Z","timestamp":1761710509683,"version":"build-2065373602"},"reference-count":0,"publisher":"CSIRO Publishing","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":10831,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,10,1]]},"abstract":"<jats:p>The endothelins are a series of peptides with potent vasoconstrictor effects in vascular tissue; however, they may also have a role as neuroendocrine secretagogues because endothelin and endothelin receptors have been found in hypothalamic and pituitary tissues. Since activation of the fetal hypothalamo-pituitary-adrenal axis is crucial to the process of parturition, the aim of this study was to determine whether endothelin could activate the hypothalamo-pituitary-adrenal axis in the ovine fetus. Catheters were inserted into the carotid artery, jugular vein and lateral cerebral ventricle of six fetal lambs at 118-122 days' gestation. After a 5-day recovery period, endothelin-3 or placebo (saline) was infused intravenously (i.v.) or intracerebroventricularly (i.c.v.) over 30-60 min. The dose of endothelin-3 employed was 0.01 and 0.1 microgram min-1 i.c.v. and 0.1 and 1.0 microgram min-1 i.v. Arterial blood was taken from the fetus before, during and for 1 h after the infusion for measurement of ACTH and cortisol. Blood gas analysis was also performed. Intravenous endothelin-3 produced a dose-dependent increase in ACTH and cortisol concentrations in fetal plasma and was associated with transient fetal hypoxia and acidosis. pH correlated inversely with plasma ACTH (r = -0.701, P &amp;lt; 0.001) and cortisol (r = -0.308, P &amp;lt; 0.001) concentration. An increase in ACTH and cortisol concentrations in fetal plasma was also induced by endothelin-3 administered i.c.v. at 0.1 microgram min-1, and this was not associated with fetal acidosis These data suggest that endothelin administered i.v. will stimulate ACTH and cortisol release indirectly through vasoconstriction and acidosis; however, the response to i.c.v. endothelin administration suggests that it may also act as a central secretagogue for ACTH in the fetus and could therefore play a role in the process of parturition.<\/jats:p>","DOI":"10.1071\/rd9951231","type":"journal-article","created":{"date-parts":[[2005,10,18]],"date-time":"2005-10-18T21:25:41Z","timestamp":1129670741000},"page":"1231-1236","source":"Crossref","is-referenced-by-count":4,"title":["Endothelin stimulates ACTH secretion in the ovine fetus"],"prefix":"10.1071","volume":"7","author":[{"given":"IA","family":"Greer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GB","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AN","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/7\/5\/1231\/303033\/rd9951231.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/7\/5\/1231\/303033\/rd9951231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:48:49Z","timestamp":1761691729000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/7\/5\/1231\/48764\/Endothelin-stimulates-ACTH-secretion-in-the-ovine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,10,1]]}},"URL":"https:\/\/doi.org\/10.1071\/rd9951231","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"type":"print","value":"1031-3613"},{"type":"electronic","value":"1448-5990"}],"subject":[],"published":{"date-parts":[[1995,10,1]]}}}