{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:33:11Z","timestamp":1782376391694,"version":"3.54.5"},"reference-count":11,"publisher":"CSIRO Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex. Health"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>\n\nBackground: The brief period of viral replication in recurrent genital herpes lesions suggests shorter therapeutic regimens may be as effective as standard 5-day courses. Objective: To demonstrate that a 2-day course of famciclovir 500 mg statim, then 250 mg twice daily was non-inferior to the standard 5-day course of 125 mg twice daily. Methods: Patients were randomly assigned either the 2-day or 5-day famciclovir course and initiated therapy within 12 h of onset of prodromal symptoms. They were instructed to complete daily questionnaires on herpes-related symptoms and functioning and to attend the clinic for assessment of healing 5.5 days after initiating therapy. Results: A total of 873 patients were randomised at least once and 1038 recurrences were treated. The proportion of evaluable recurrences with lesions present at 5.5 days was less in the 2-day arm (24%) than in the 5-day (28%) arm. The upper 97.5% confidence limit (CL) for this difference in favour of the 2-day arm was 2% in favour of the 5-day arm, well within the 10% predefined for non-inferiority. The upper 97.5% CL was similar in the intent-to-treat, evaluable and per-protocol recurrence populations and when adjusted for baseline differences (in gender, age, herpes history and HIV infection) or for clustering of recurrences within patients. Both treatments had similar side-effects; proportion of lesions aborted; time to next recurrence; patient-reported symptoms; and impact on daily functioning. Conclusions: The 2-day course was as safe and effective as the standard 5-day course and can only enhance patient convenience and compliance.\n<\/jats:p>","DOI":"10.1071\/sh08013","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T02:12:17Z","timestamp":1234231937000},"page":"219","source":"Crossref","is-referenced-by-count":32,"title":["2-day versus 5-day famciclovir as treatment of recurrences of genital herpes: results of the FaST study"],"prefix":"10.1071","volume":"5","author":[{"given":"Neil","family":"Bodsworth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"McNulty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Denham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Doong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Trottier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Adena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Ann","family":"Bonney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Agnew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Australo-Canadian FaST (Famciclovir Short-Course Herpes Therapy) Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","reference":[{"key":"SH08013R2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1086\/339325","volume":"34","author":"Wald","year":"2002","journal-title":"Clin Infect Dis"},{"key":"SH08013R3","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1086\/339326","volume":"34","author":"Leone","year":"2002","journal-title":"Clin Infect Dis"},{"key":"SH08013R4","first-page":"327","volume":"64","author":"Goldmeier","year":"1988","journal-title":"Genitourin Med"},{"key":"SH08013R5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1037\/0278-6133.6.1.57","volume":"6","author":"Vanderplate","year":"1987","journal-title":"Health Psychol"},{"key":"SH08013R6","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2165\/00019053-200321120-00002","volume":"21","author":"Brentjens","year":"2003","journal-title":"Pharmacoeconomics"},{"key":"SH08013R7","first-page":"in press","author":"Meads","year":"2008","journal-title":"Value in Health"},{"key":"SH08013R8","first-page":"110","volume":"73","author":"Bodsworth","year":"1997","journal-title":"Genitourin Med"},{"key":"SH08013R9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/jac\/44.4.525","volume":"44","author":"Saiag","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"SH08013R10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1086\/498521","volume":"42","author":"Aoki","year":"2006","journal-title":"Clin Infect Dis"},{"key":"SH08013R11","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1136\/sti.75.6.398","volume":"75","author":"Patel","year":"1999","journal-title":"Sex Transm Infect"},{"key":"SH08013R12","first-page":"457","volume":"69","author":"Carney","year":"1993","journal-title":"Genitourin Med"}],"container-title":["Sexual Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.publish.csiro.au\/SH\/pdf\/SH08013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T03:41:42Z","timestamp":1542944502000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.publish.csiro.au\/?paper=SH08013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008]]}},"alternative-id":["SH08013"],"URL":"https:\/\/doi.org\/10.1071\/sh08013","relation":{},"ISSN":["1448-5028"],"issn-type":[{"value":"1448-5028","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]}}}