{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T13:38:03Z","timestamp":1771940283709,"version":"3.50.1"},"reference-count":26,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":5215,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,24]]},"abstract":"<jats:p>Background: HIV and highly active antiretroviral therapies have been associated with changes in individuals\u2019 lipid profiles and fat distribution (lipodystrophy). A pilot study was conducted for a randomised controlled trial to evaluate whether lipodystrophy in HIV patients can be controlled by adopting the low-fat and low-cholesterol diet or the modified Mediterranean diet. Methods: Forty-eight HIV patients were randomised into two diet groups. Thirty-six (75%) completed the 1-year pilot study with regular dietetic consultations, during which time lipid levels, weight, body mass index and fat distribution were recorded. Differences between and within groups were determined. Results: Undesirable body fat changes in the low-fat diet group included decreases in tricep skinfold (from 19.9 mm to 15.4 mm (P = 0.03)), hip circumference (from 93.6 cm to 91.7 cm (P = 0.01)) but a significant increase in waist-to-hip ratio (from 0.87 to 0.89 (P = 0.003)). Serum cholesterol increased significantly in the Mediterranean diet group at 9 and 12 months (from 4.6 to 5.06 mmol L-1 (P = 0.03) and 5.12 mmol L-1 (P = 0.01)) with no obvious change in the low-fat diet group. Serum triglyceride levels remained the same in the Mediterranean diet group, whereas it increased from 1.9 to 3.22 mmol L-1 (P = 0.07) in the low-fat diet group. Conclusions: A Mediterranean diet seems to have an advantage over the low-fat diet in maintaining serum triglyceride levels and avoiding lipodystrophy, but this advantage was offset by a rise in cholesterol level. Several procedural and methodological issues were identified which must be rectified before a similar large-scale trial taking place.<\/jats:p>","DOI":"10.1071\/sh09065","type":"journal-article","created":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T19:24:28Z","timestamp":1295897068000},"page":"43-51","source":"Crossref","is-referenced-by-count":13,"title":["Can a Mediterranean diet reduce the effects of lipodystrophy syndrome in people living with HIV? A pilot randomised controlled trial"],"prefix":"10.1071","volume":"8","author":[{"given":"Geraldine Wai Bik","family":"Ng","sequence":"first","affiliation":[{"name":"ADepartment of Dietetics, Queen Elizabeth Hospital, Kowloon, Hong Kong."},{"name":"DCorresponding author. Emails:"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Una Man Shu","family":"Chan","sequence":"additional","affiliation":[{"name":"ADepartment of Dietetics, Queen Elizabeth Hospital, Kowloon, Hong Kong."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick Chung Ki","family":"Li","sequence":"additional","affiliation":[{"name":"BDepartment of Medicine, Queen Elizabeth Hospital, Kowloon, Hong Kong."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C. W.","family":"Wong","sequence":"additional","affiliation":[{"name":"CDepartment of Family Medicine and Primary Care, The University of Hong Kong, Ap Lei Chau, Hong Kong."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2011,1,24]]},"reference":[{"key":"2025102418594812500_R1"},{"key":"2025102418594812500_R2"},{"key":"2025102418594812500_R3"},{"key":"2025102418594812500_R4"},{"key":"2025102418594812500_R5"},{"key":"2025102418594812500_R6"},{"key":"2025102418594812500_R7"},{"key":"2025102418594812500_R8"},{"key":"2025102418594812500_R9"},{"key":"2025102418594812500_R10"},{"key":"2025102418594812500_R11"},{"key":"2025102418594812500_R12"},{"key":"2025102418594812500_R13"},{"key":"2025102418594812500_R14"},{"key":"2025102418594812500_R15"},{"key":"2025102418594812500_R16"},{"key":"2025102418594812500_R17"},{"key":"2025102418594812500_R18"},{"key":"2025102418594812500_R19"},{"key":"2025102418594812500_R20"},{"key":"2025102418594812500_R21"},{"key":"2025102418594812500_R22"},{"key":"2025102418594812500_R23"},{"key":"2025102418594812500_R24"},{"key":"2025102418594812500_R25"},{"key":"2025102418594812500_R26"}],"container-title":["Sexual Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/8\/1\/43\/144095\/sh09065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/8\/1\/43\/144095\/sh09065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T22:59:52Z","timestamp":1761346792000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/sh\/article\/8\/1\/43\/20944\/Can-a-Mediterranean-diet-reduce-the-effects-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,24]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1,24]]}},"URL":"https:\/\/doi.org\/10.1071\/sh09065","relation":{},"ISSN":["1448-5028","1449-8987"],"issn-type":[{"value":"1448-5028","type":"print"},{"value":"1449-8987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,24]]}}}