{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:50:16Z","timestamp":1761519016210,"version":"build-2065373602"},"reference-count":24,"publisher":"CSIRO Publishing","issue":"3","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":5212,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,17]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is currently limited information about human papillomavirus (HPV) genotype distribution in women in the South Pacific region. This study\u2019s objective was to determine HPV genotypes present in cervical cancer (CC) and precancers (cervical intraepithelial lesion (CIN) 3) in Fiji. Methods: Cross-sectional analysis evaluated archival CC and CIN3 biopsy samples from 296 women of Melanesian Fijian ethnicity (n = 182, 61.5%) and Indo-Fijian ethnicity (n = 114, 38.5%). HPV genotypes were evaluated using the INNO-LiPA assay in archival samples from CC (n = 174) and CIN3 (n = 122) among women in Fiji over a 5-year period from 2003 to 2007. Results: Overall, 99% of the specimens tested were HPV DNA-positive for high-risk genotypes, with detection rates of 100%, 97.4% and 100% in CIN3, squamous cell carcinoma (SCC) and adenosquamous carcinoma biopsies, respectively. Genotypes 16 and 18 were the most common (77%), followed by HPV 31 (4.3%). Genotype HPV 16 was the most common identified (59%) in CIN3 specimens, followed by HPV 31 (9%) and HPV 52 (6.6%). Multiple genotypes were detected in 12.5\u201333.3% of specimens, depending on the pathology. Conclusion: These results indicated that the two most prevalent CC-associated HPV genotypes in Fiji parallel those described in other regions worldwide, with genotype variations thereafter. These data suggest that the currently available bivalent and quadrivalent HPV vaccines could potentially reduce cervical cancers in Fiji by over 80% and reduce precancers by at least 60%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh10083","type":"journal-article","created":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T00:54:00Z","timestamp":1305248040000},"page":"338-342","source":"Crossref","is-referenced-by-count":10,"title":["Human papillomavirus genotype prevalence in cervical biopsies from women diagnosed with cervical intraepithelial neoplasia or cervical cancer in Fiji"],"prefix":"10.1071","volume":"8","author":[{"given":"Sepehr N.","family":"Tabrizi","sequence":"first","affiliation":[{"name":"ARegional WHO HPV Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women\u2019s Hospital, Parkville, Vic. 3052, Australia."},{"name":"BDepartment of Obstetrics and Gynaecology, University of Melbourne, The Royal Women\u2019s Hospital and Murdoch Children\u2019s Research Institute, Parkville, Vic. 3052, Australia."},{"name":"HCorresponding author. Email: Sepehr.tabrizi@thewomens.org.au"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin","family":"Law","sequence":"additional","affiliation":[{"name":"CCentre for International Child Health, Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital, Department of Paediatrics, University of Melbourne, Parkville, Vic. 3052, Australia."},{"name":"DNational Centre for Epidemiology and Population Health, Australian National University, Acton, ACT 0200, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eka","family":"Buadromo","sequence":"additional","affiliation":[{"name":"EMinistry of Health, Suva, Fiji."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Stevens","sequence":"additional","affiliation":[{"name":"ARegional WHO HPV Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women\u2019s Hospital, Parkville, Vic. 3052, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Fong","sequence":"additional","affiliation":[{"name":"EMinistry of Health, Suva, Fiji."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josaia","family":"Samuela","sequence":"additional","affiliation":[{"name":"EMinistry of Health, Suva, Fiji."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahomed","family":"Patel","sequence":"additional","affiliation":[{"name":"DNational Centre for Epidemiology and Population Health, Australian National University, Acton, ACT 0200, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Kim","family":"Mulholland","sequence":"additional","affiliation":[{"name":"FMenzies School of Health Research, Department of Child Health, Darwin, NT 0811, Australia."},{"name":"GLondon School of Hygiene and Tropical Medicine, University of London, WC1E 7HT, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona M.","family":"Russell","sequence":"additional","affiliation":[{"name":"CCentre for International Child Health, Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital, Department of Paediatrics, University of Melbourne, Parkville, Vic. 3052, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Garland","sequence":"additional","affiliation":[{"name":"ARegional WHO HPV Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women\u2019s Hospital, Parkville, Vic. 3052, Australia."},{"name":"BDepartment of Obstetrics and Gynaecology, University of Melbourne, The Royal 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