{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:50:35Z","timestamp":1761630635325,"version":"build-2065373602"},"reference-count":28,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":4634,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although anal squamous cell carcinomas (ASCC) are rare in the general community, rates of ASCC among HIV-positive men who have sex with men (MSM) approach those of major cancers in the general community, such as colorectal and lung cancers. Anal cytology and high-resolution anoscopy (HRA) have been proposed as methods for the diagnosis of high-grade anal intraepithelial neoplasia (HGAIN), the precursor of ASCC. To determine the prevalence of anal disease among HIV-positive MSM, we investigated anal cytological and histological findings in men from a large HIV clinic in Sydney, Australia. Methods: This was a single-centre study conducted between October 2008 and January 2010. Participants self-collected cytology specimens, and those yielding abnormal cytology results of atypical cells of undetermined significance, atypical cells of undetermined significance \u2013 possibly high-grade (ASC-H) and high-grade squamous intraepithelial lesions (HSIL) were offered HRA. In addition, of those yielding low-grade squamous intraepithelial lesions results, a systematically selected group (25%) were offered HRA. Results: Of the 1339 HIV-positive MSM who attended the clinic during the study period, 291 (31.8%) were finally included in the study, 262 yielded technically satisfactory cytological results and 101 (36.7%) participants underwent HRA. HGAIN was identified in 55 (54.5%) of the 101 men undergoing HRA. HGAIN was diagnosed in 28 (52.7%) without cytological ASC-H or HSIL results. Conclusions: Despite the poor correlation between anal cytological and histological findings, high levels of HGAIN were identified in HIV-positive MSM attending this clinical service.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh11135","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T23:32:40Z","timestamp":1356046360000},"page":"9-17","source":"Crossref","is-referenced-by-count":15,"title":["Anal cytological abnormalities are poor predictors of high-grade intraepithelial neoplasia amongst HIV-positive men who have sex with men"],"prefix":"10.1071","volume":"10","author":[{"given":"Leon P.","family":"Botes","sequence":"first","affiliation":[{"name":"AWestern Sydney Sexual Health Centre, Parramatta, NSW 2150, Australia."},{"name":"BCentre for Applied Medical Research, St Vincent\u2019s Hospital, Sydney, NSW 2010, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Pett","sequence":"additional","affiliation":[{"name":"BCentre for Applied Medical Research, St Vincent\u2019s Hospital, Sydney, NSW 2010, Australia."},{"name":"CThe Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Carr","sequence":"additional","affiliation":[{"name":"BCentre for Applied Medical Research, St Vincent\u2019s Hospital, Sydney, NSW 2010, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"Marriott","sequence":"additional","affiliation":[{"name":"BCentre for Applied Medical Research, St Vincent\u2019s Hospital, Sydney, NSW 2010, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"BCentre for Applied Medical Research, St Vincent\u2019s Hospital, Sydney, NSW 2010, Australia."},{"name":"CThe Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Matthews","sequence":"additional","affiliation":[{"name":"BCentre for Applied Medical Research, St Vincent\u2019s Hospital, Sydney, NSW 2010, Australia."},{"name":"CThe Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Carbone","sequence":"additional","affiliation":[{"name":"DSydPath Laboratories, St Vincent\u2019s Hospital, Sydney, NSW 2010, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmala","family":"Kumaradevan","sequence":"additional","affiliation":[{"name":"DSydPath Laboratories, St Vincent\u2019s Hospital, Sydney, NSW 2010, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"McHugh","sequence":"additional","affiliation":[{"name":"AWestern Sydney Sexual Health Centre, Parramatta, NSW 2150, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Hillman","sequence":"additional","affiliation":[{"name":"AWestern Sydney Sexual Health Centre, Parramatta, NSW 2150, Australia."},{"name":"BCentre for Applied Medical Research, St Vincent\u2019s Hospital, Sydney, NSW 2010, Australia."},{"name":"CThe Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia."},{"name":"ECorresponding author. Email: richard.hillman@sydney.edu.au"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"key":"2025102617033781400_R1","unstructured":"Australian Institute of Health and Welfare (AIHW). Cancer in Australia: an overview, 2008. Canberra: AIHW ; 2008. 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