{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:28:29Z","timestamp":1765704509524,"version":"build-2065373602"},"reference-count":37,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":4858,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,27]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We report the prevalence and predictors for high-grade anal intraepithelial neoplasia (HGAIN) in community-based cohorts of HIV-negative and HIV-positive homosexual men in Sydney, Australia. Methods: A cross-sectional study of consecutive participants in both cohorts was performed in 2005 (204 HIV-negative and 128 HIV-positive men). Anal swabs collected by a research nurse underwent cytological analysis, using the ThinPrep procedure, and human papillomavirus (HPV) testing. Participants who had cytological abnormalities other than low-grade squamous epithelial lesions (SIL) were referred for high resolution anoscopy (HRA). Results: A total of 114 men had cytological abnormalities (24.3% of HIV-negative and 57.5% of HIV-positive men, odds ratio (OR) = 4.21, 95% confidence interval (CI) 2.57\u20136.90). However, only three (2.3%) HIV-positive men and no HIV-negative men had high-grade SIL on anal cytology. Seventy-seven men were referred for HRA, of whom 63 (81.8%) attended. Histologically confirmed HGAIN was detected in 21 (33.3%). The prevalence of HGAIN was higher in HIV-positive men (10.8%) than in HIV-negative men (5.0%, OR = 2.29, 95% CI 0.93\u20135.63, P = 0.071). HGAIN was not related to age but was strongly associated with the detection of high-risk types of anal HPV (OR = 10.1, 95% CI 1.33\u201376.2) rather than low-risk types (OR = 1.97, 95% CI 0.74\u20135.25). Conclusion: HGAIN was prevalent in homosexual men across all age groups and was more than twice as common in HIV-positive men compared with HIV-negative men. The presence of high-risk anal HPV was highly predictive of HGAIN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh11139","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T23:20:10Z","timestamp":1353972010000},"page":"574-579","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence and predictors of high-grade anal intraepithelial neoplasia in a community-based sample of homosexual men"],"prefix":"10.1071","volume":"9","author":[{"given":"Richard J.","family":"Hillman","sequence":"first","affiliation":[{"name":"ASexually Transmitted Infections Research Centre, University of Sydney, Marion Villa, Westmead, NSW 2145, Australia."},{"name":"FCorresponding author. Email: richard.hillman@sydney.edu.au"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina T.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"BKirby Institute, University of New South Wales, Darlinghurst, NSW 2010, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire M.","family":"Vajdic","sequence":"additional","affiliation":[{"name":"CPrince of Wales Clinical School and Lowy Cancer Research Centre, Faculty of Medicine, Building C25, Faculty of Medicine, Kensington Campus, University of New South Wales, NSW 2052, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"McHugh","sequence":"additional","affiliation":[{"name":"ASexually Transmitted Infections Research Centre, University of Sydney, Marion Villa, Westmead, NSW 2145, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garrett P.","family":"Prestage","sequence":"additional","affiliation":[{"name":"BKirby Institute, University of New South Wales, Darlinghurst, NSW 2010, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon P.","family":"Botes","sequence":"additional","affiliation":[{"name":"ASexually Transmitted Infections Research Centre, University of Sydney, Marion Villa, Westmead, NSW 2145, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna","family":"Zablotska","sequence":"additional","affiliation":[{"name":"BKirby Institute, University of New South Wales, Darlinghurst, NSW 2010, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Medley","sequence":"additional","affiliation":[{"name":"DMelbourne Pathology, Private Bag 5, Collingwood, Vic. 3066, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepehr 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