{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T14:40:00Z","timestamp":1782052800022,"version":"3.54.5"},"reference-count":14,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":2461,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pre-exposure prophylaxis (PrEP) was introduced in Sexual Health Services of the Welsh National Health Service (NHS Wales) in July 2017 as a 3-year pilot service. Methods: Data were collected through the pre-existing Sexual Health in Wales Surveillance System, to which codes were added to capture PrEP eligibility, outcome of offer of PrEP, reasons for declining and adherence. Eligibility categories were defined based on nationally agreed criteria: men who have sex with men (MSM) and transgender people at high risk of HIV acquisition; partners of HIV-positive individuals not known to be virally suppressed; and heterosexuals reporting condomless intercourse with a HIV-positive individual not known to be virally suppressed. Results: During the first 6 months, 516 people were eligible, 96% of which were MSM. Overall, 57% of those eligible (296\/516) started PrEP. Reasons for declining PrEP were given by 88 (56%) of 157 people; 50 (57%) of whom did not believe themselves to be at risk. Of the available adherence assessments, 89% considered that all risk episodes had been covered. Persistence at 3 months was assessed for 141 people, of which 93 (66%) were still using PrEP. There were no HIV diagnoses in people taking PrEP during the first 6 months. Twenty-nine people were diagnosed with 37 episodes of sexually transmissible infections (STIs) while on PrEP. STI incidence was 105.7 per 100 person-years. Conclusions: The early trend indicates that implementation of PrEP is progressing as planned, and the service has been utilised by clients. This analysis can help refine implementation, inform planning and research around uptake, use and effect in Wales and internationally.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh18091","type":"journal-article","created":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T19:00:57Z","timestamp":1543777257000},"page":"56-62","source":"Crossref","is-referenced-by-count":8,"title":["Early experience of implementing a national HIV pre-exposure prophylaxis service in Wales, United Kingdom 2017"],"prefix":"10.1071","volume":"16","author":[{"given":"Laia","family":"Fina","sequence":"first","affiliation":[{"name":"APublic Health Wales, 2 Capital Quarter, Tyndall Street, CF10 4BZ Cardiff, Wales."},{"name":"BEuropean Program for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Gustav III:s Boulevard 40, 16973 Solna, Stockholm, Sweden."},{"name":"DCorresponding author. Email: laia.fina@wales.nhs.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Phillips","sequence":"additional","affiliation":[{"name":"APublic Health Wales, 2 Capital Quarter, Tyndall Street, CF10 4BZ Cardiff, Wales."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam T.","family":"Jones","sequence":"additional","affiliation":[{"name":"APublic Health Wales, 2 Capital Quarter, Tyndall Street, CF10 4BZ Cardiff, Wales."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00eb M.","family":"Couzens","sequence":"additional","affiliation":[{"name":"APublic Health Wales, 2 Capital Quarter, Tyndall Street, CF10 4BZ Cardiff, Wales."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Drayton","sequence":"additional","affiliation":[{"name":"CCardiff and Vale University Health Board, Cardiff Royal Infirmary, Glossop Road, CF24 0SZ, Cardiff, Wales."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Rh.","family":"Thomas","sequence":"additional","affiliation":[{"name":"APublic Health Wales, 2 Capital Quarter, Tyndall Street, CF10 4BZ Cardiff, Wales."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda Giri","family":"Shankar","sequence":"additional","affiliation":[{"name":"APublic Health Wales, 2 Capital Quarter, Tyndall Street, CF10 4BZ Cardiff, Wales."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"2025102617154011600_R1","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS). UNAIDS Data 2017. Geneva: UNAIDS; 2017. Available online at: http:\/\/www.unaids.org\/en\/resources\/documents\/2017\/2017_data_book [verified 10 April 2018]."},{"key":"2025102617154011600_R2","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1056\/NEJMoa1011205","article-title":"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.","volume":"363","author":"Grant","year":"2010","journal-title":"N Engl J Med"},{"key":"2025102617154011600_R3","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1056\/NEJMoa1108524","article-title":"Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.","volume":"367","author":"Baeten","year":"2012","journal-title":"N Engl J Med"},{"key":"2025102617154011600_R4","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1056\/NEJMoa1110711","article-title":"Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana.","volume":"367","author":"Thigpen","year":"2012","journal-title":"N Engl J Med"},{"key":"2025102617154011600_R5","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1016\/S0140-6736(13)61127-7","article-title":"Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial.","volume":"381","author":"Choopanya","year":"2013","journal-title":"Lancet"},{"key":"2025102617154011600_R6","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1056\/NEJMoa1506273","article-title":"On-demand preexposure prophylaxis in men at high risk for HIV-1 infection.","volume":"373","author":"Molina","year":"2015","journal-title":"N Engl J Med"},{"key":"2025102617154011600_R7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0140-6736(15)00056-2","article-title":"Preexposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial.","volume":"387","author":"McCormack","year":"2016","journal-title":"Lancet"},{"key":"2025102617154011600_R8","unstructured":"Welsh Government. Health Secretary, Vaughan Gething, announces all-Wales PrEP trial. Cardiff: Welsh Government; 2017. Available online at: http:\/\/gov.wales\/newsroom\/health-and-social-services\/2017\/170428trial\/?lang=en [verified 24 March 2018]."},{"key":"2025102617154011600_R9","unstructured":"Public Health Wales. \u2018Preparing for PrEP?\u2019 A Review of the Current Evidence for Pre-Exposure Prophylaxis (PrEP) to prevent HIV infection in Wales. Cardiff: Public Health Wales; 2017. Available online at: http:\/\/www.wales.nhs.uk\/sitesplus\/888\/opendoc\/304708 [verified 24 March 2018]."},{"key":"2025102617154011600_R10","unstructured":"All Wales Medicines Strategy Group (AWMSG). Emtricitabine\/tenofovir disoproxil fumarate (Truvada). Cardiff: AWMSG; 2017. Available online at: http:\/\/www.awmsg.org\/awmsgonline\/app\/appraisalinfo\/1625 [verified 6 May 2017]."},{"key":"2025102617154011600_R11","unstructured":"Public Health Wales. Pre-Exposure Prophylaxis (PrEP) Management Guidelines. Cardiff: Public Health Wales NHS Trust; 2017. Available online at: http:\/\/www.publichealthnetwork.cymru\/files\/3814\/9458\/8248\/PrEP_Management_Guidelines_2017_12_05_17.docx [verified 12 May 2017]."},{"issue":"16","key":"2025102617154011600_R12","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1097\/QAD.0000000000001627","article-title":"Pre-exposure prophylaxis for MSM and transgender persons in early adopting countries.","volume":"31","author":"Hoornenborg","year":"2017","journal-title":"AIDS"},{"issue":"1","key":"2025102617154011600_R13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/COH.0000000000000220","article-title":"Current concepts for PrEP adherence in the PrEP revolution: from clinical trials to routine practice.","volume":"11","author":"Haberer","year":"2016","journal-title":"Curr Opin HIV AIDS"},{"issue":"4","key":"2025102617154011600_R14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/QAD.0000000000001718","article-title":"Incidence of sexually transmitted infections before and after preexposure prophylaxis for HIV.","volume":"32","author":"Nguyen","year":"2018","journal-title":"AIDS"}],"container-title":["Sexual Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/16\/1\/56\/1255660\/sh18091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/16\/1\/56\/1255660\/sh18091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:15:47Z","timestamp":1761513347000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/sh\/article\/16\/1\/56\/185046\/Early-experience-of-implementing-a-national-HIV"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2,4]]}},"URL":"https:\/\/doi.org\/10.1071\/sh18091","relation":{},"ISSN":["1448-5028","1449-8987"],"issn-type":[{"value":"1448-5028","type":"print"},{"value":"1449-8987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]}}}