{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:21:01Z","timestamp":1790263261377,"version":"4.1.0"},"reference-count":78,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":2465,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,29]]},"abstract":"<jats:p>In September 2015, the World Health Organization (WHO) launched evidence-based guidelines by recommending that any person at substantial HIV risk should be offered oral pre-exposure prophylaxis (PrEP) containing tenofovir disoproxil fumarate (TDF) as an additional prevention choice. Since 2017, PrEP medicines have also been listed in the WHO\u2019s Essential Medicines List, including TDF\/emtricitabine (FTC) and TDF in combination with lamivudine (3TC). A descriptive policy review and analysis of countries adopting WHO\u2019s 2015 recommendation on oral PrEP was conducted. As of June 2018, we identified 35 countries that had some type of policy on oral PrEP, and an additional five countries where a specific policy on PrEP is currently pending. A total of 19 high-income countries (HICs) and 21 low- and middle-income countries (LMICs) have adopted or have a pending policy. Most countries that have adopted or pending PrEP are in the European (42.9%) or African (30.0%) region. TDF\/FTC is the most commonly recommended PrEP drug in the guidelines reviewed, although seven countries, namely in sub-Saharan Africa (6\/7), are also recommending the use of TDF\/3TC for PrEP. In sum, by the end of 2018, at least 40 countries (20.6%) are anticipated to have adopted WHO\u2019s oral PrEP recommendation. Nonetheless, policy uptake does not reflect broader programmatic coverage of PrEP services, which remain limited across all settings, irrespective of income status. Enhancing global partnerships is needed to support and track ongoing policy adoption and to ensure that policy is translated into meaningful implementation of PrEP services.<\/jats:p>","DOI":"10.1071\/sh18125","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T21:02:16Z","timestamp":1543438936000},"page":"489-500","source":"Crossref","is-referenced-by-count":75,"title":["Going global: the adoption of the World Health Organization\u2019s enabling recommendation on oral pre-exposure prophylaxis for HIV"],"prefix":"10.1071","volume":"15","author":[{"given":"Ioannis","family":"Hodges-Mameletzis","sequence":"first","affiliation":[{"name":"AWorld Health Organization, Headquarters, Avenue Appia 20, 1202 Geneva, Switzerland."},{"name":"CCorresponding author. 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