{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:15:48Z","timestamp":1775560548592,"version":"3.50.1"},"reference-count":31,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":1525,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Philippines HIV epidemic is one of the fastest growing, globally. Infections among men who have sex with men (MSM) are rising at an alarming rate, necessitating targeted evidence-based interventions to reach epidemic control. Treatment as prevention is a key strategy to end AIDS, making it a priority to explore novel approaches to retain people living with HIV (PLHIV) in care, support adherence, and reach viral suppression. Methods: This cross-sectional analysis describes HIV-related risk behaviours and adherence to antiretroviral therapy (ART) in a population of HIV-positive patients at a clinic in Metro Manila, Philippines participating in the Philippines Connect for LifeTM cohort study. Results: Among 426 HIV-positive adults taking ART, 79% reported \u226595% adherence over the prior 30 days. Longer time on treatment was associated with reduced adherence to ART (adjusted odds ratio (AOR) = 0.87 per year, P = 0.027). Being in a serodiscordant relationship, in which the subject\u2019s primary partner was HIV negative, increased adherence (AOR = 3.19, P = 0.006). Inconsistent condom use (AOR = 0.50, P = 0.103) and injection drug use (AOR = 0.54, P = 0.090) are potentially associated with reduced adherence to ART. Patients used drugs and alcohol at significantly higher rates than the general population.? Conclusions: The study found that patients in this setting require intervention to address treatment fatigue. Interventions to improve social support of PLHIV, as well as harm-reduction approaches for drug and alcohol use, could improve adherence in this population, strengthening the test-and-treat strategy to control the epidemic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh20028","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T02:44:24Z","timestamp":1614653064000},"page":"95-103","source":"Crossref","is-referenced-by-count":15,"title":["Risk factors affecting adherence to antiretroviral therapy among HIV patients in Manila, Philippines: a baseline cross-sectional analysis of the Philippines Connect for Life Study"],"prefix":"10.1071","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3372-8319","authenticated-orcid":true,"given":"Cara","family":"O\u2019Connor","sequence":"first","affiliation":[{"name":"ASustained Health Initiatives of the Philippines (SHIP), Mandaluyong, Philippines."},{"name":"BLondon School of Hygiene and Tropical Medicine, London, UK."},{"name":"CWits Reproductive Health and HIV Research Institute, Johannesburg, South Africa."},{"name":"HCorresponding author. Email: coconnor@ship.ph"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Leyritana","sequence":"additional","affiliation":[{"name":"ASustained Health Initiatives of the Philippines (SHIP), Mandaluyong, Philippines."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris","family":"Calica","sequence":"additional","affiliation":[{"name":"ASustained Health Initiatives of the Philippines (SHIP), Mandaluyong, Philippines."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randeep","family":"Gill","sequence":"additional","affiliation":[{"name":"DJohnson & Johnson Global Public Health, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoife M.","family":"Doyle","sequence":"additional","affiliation":[{"name":"BLondon School of Hygiene and Tropical Medicine, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Lewis","sequence":"additional","affiliation":[{"name":"EY Lab, The Public Services Innovation Lab for Wales, School of Social Sciences, Cardiff University, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edsel Maurice","family":"Salva\u00f1a","sequence":"additional","affiliation":[{"name":"FInstitute of Molecular Biology and Biotechnology, National Institutes of Health, University of the Philippines Manila, Ermita, Philippines."},{"name":"GSection of Infectious Disease, Department of Medicine, University of the Philippines College of Medicine, University of the Philippines Manila, Ermita, Philippines."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"issue":"2","key":"2025111802152918900_R1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30265-2","article-title":"HIV crisis in the Philippines: urgent actions needed.","volume":"4","author":"Gangcuangco","year":"2019","journal-title":"Lancet Public Health"},{"key":"2025111802152918900_R2","unstructured":"Geronimo JY. WHO: PH has fastest growing HIV epidemic in the world. Rappler, 20 May 2015. Available online at: http:\/\/www.rappler.com\/nation\/93839-who-ph-response-hiv [verified 27 December 2020]."},{"issue":"10095","key":"2025111802152918900_R3","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/S0140-6736(17)32211-0","article-title":"Losing the fight against HIV in the Philippines.","volume":"390","author":"The Lancet","year":"2017","journal-title":"Lancet"},{"key":"2025111802152918900_R4","unstructured":"Department of Health Philippines, Epidemiology Bureau. HIV\/AIDS and ART registry of the Philippines, March 2019. 2019. Available online at: https:\/\/doh.gov.ph\/sites\/default\/files\/statistics\/HIV_STAT_2019MAR.pdf [verified 27 December 2020]."},{"key":"2025111802152918900_R5","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS). UNAIDS data 2017. 2017. 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