{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:55:28Z","timestamp":1761508528510,"version":"build-2065373602"},"reference-count":5,"publisher":"CSIRO Publishing","issue":"3","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":1880,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:p>The use of tenofovir disoproxil fumarate (TDF) in combination with emtricitabine, prescribed for pre-exposure prophylaxis (PrEP), is highly effective at reducing incident sexually transmissible HIV infection among those at risk. TDF is associated with proteinuria, Fanconi syndrome and chronic kidney disease, and is not recommended for use in patients with an estimated creatinine clearance &amp;lt;60 mL min\u22121. There are currently no Pharmaceutical Benefits Scheme (PBS)-funded PrEP options for patients at risk of HIV infection with moderate renal impairment in Australia. This report describes the case of a patient who acquired HIV soon after PrEP was suspended due to moderate renal impairment. The various clinical and regulatory issues this case raises are discussed.<\/jats:p>","DOI":"10.1071\/sh20037","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:05:04Z","timestamp":1592957104000},"page":"299-300","source":"Crossref","is-referenced-by-count":1,"title":["Renal impairment: an unnecessary barrier to HIV prevention"],"prefix":"10.1071","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-4754","authenticated-orcid":true,"given":"Jack E.","family":"Heron","sequence":"first","affiliation":[{"name":"ADepartment of Renal Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia."},{"name":"DCorresponding author. Email: Jack.Heron@health.nsw.gov.au"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Rix","sequence":"additional","affiliation":[{"name":"BSydney Sexual Health Centre, South Eastern Sydney Local Health District, Sydney, NSW 2000, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Varma","sequence":"additional","affiliation":[{"name":"BSydney Sexual Health Centre, South Eastern Sydney Local Health District, Sydney, NSW 2000, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Gracey","sequence":"additional","affiliation":[{"name":"ADepartment of Renal Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia."},{"name":"CCentral Clinical School, The University of Sydney, Sydney, NSW 2006, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"2025102615485193400_R1","unstructured":"Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM). The ASHM PrEP guidelines: Sept 2019 update. Sydney: ASHM; 2019. Available online at: https:\/\/ashm.org.au\/resources\/hiv-resources-list\/prep-guidelines-2019\/ [verified 22 May 2020]."},{"issue":"12","key":"2025102615485193400_R2","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1097\/QAD.0000000000001145","article-title":"Effectiveness and safety of oral HIV preexposure prophylaxis for all populations.","volume":"30","author":"Fonner","year":"2016","journal-title":"AIDS"},{"issue":"4","key":"2025102615485193400_R3","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/QAI.0000000000000868","article-title":"Reversibility of glomerular renal function decline in HIV-uninfected men and women discontinuing emtricitabine-tenofovir disoproxil fumarate pre-exposure prophylaxis.","volume":"71","author":"Mugwanya","year":"2016","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"23","key":"2025102615485193400_R4","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1056\/NEJMoa1506273","article-title":"On-demand preexposure prophylaxis in men at high risk for HIV-1 infection.","volume":"373","author":"Molina","year":"2015","journal-title":"N Engl J Med"},{"key":"2025102615485193400_R5","unstructured":"Hare CB, Coll J, Ruane P, Molina J, Mayer K, Jessen H, et al., editors. The phase 3 DISCOVER study: daily F\/TAF or F\/TDF for HIV preexposure prophylaxis. Proceedings of the Conference on Retroviruses and Opportunistic Infections; 4\u20137 March 2019; Seattle, WA, USA. San Francisco: CROI Foundation; 2019. Available online at: https:\/\/www.croiconference.org\/abstract\/phase-3-discover-study-daily-ftaf-or-ftdf-hiv-preexposure-prophylaxis\/ [verified 22 May 2020]."}],"container-title":["Sexual Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/17\/3\/299\/756169\/sh20037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/17\/3\/299\/756169\/sh20037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:48:56Z","timestamp":1761508136000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/sh\/article\/17\/3\/299\/92911\/Renal-impairment-an-unnecessary-barrier-to-HIV"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,24]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6,30]]}},"URL":"https:\/\/doi.org\/10.1071\/sh20037","relation":{},"ISSN":["1448-5028","1449-8987"],"issn-type":[{"type":"print","value":"1448-5028"},{"type":"electronic","value":"1449-8987"}],"subject":[],"published":{"date-parts":[[2020,6,24]]}}}