{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:00:11Z","timestamp":1776448811193,"version":"3.51.2"},"reference-count":34,"publisher":"CSIRO Publishing","issue":"4","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":1341,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The uncertainty of how neurosyphilis is diagnosed and treated in clinical settings led us to investigate whether this serious manifestation of syphilis infection is properly managed in China. Methods: This national cross-sectional study of the diagnosis and treatment of neurosyphilis included 1392 clinicians at 398 hospitals located in 116 cities in China. Results: Of 398 hospitals, 244 (61.3%) failed to perform diagnostic laboratory tests and 181 (45.5%) failed to provide recommended treatment for neurosyphilis. Of 1392 clinicians, 536 (38.5%) had previously diagnosed patients with neurosyphilis, but 419 (78.2%) of the latter provided diagnoses that did not meet the criteria set by national guidelines. Of the 485 clinicians who had previously treated patients with neurosyphilis, 280 (57.7%) failed to follow national guidelines for treatment. Analysis indicated that clinicians working in North China (adjusted odds ratio (aOR), 4.24; 95% confidence interval (CI), 1.65\u201310.88), tertiary hospitals (aOR, 3.23; 95% CI, 1.63\u20136.41), and hospitals specialising in sexually transmitted infections (aOR, 2.49; 95% CI, 1.24\u20134.99) were more likely to follow national guidelines for neurosyphilis treatment. Conclusion: Lack of knowledge in disease management poses a great obstacle to prevent the serious consequences of neurosyphilis in Chinese patients. More effective measures are urgently needed to improve this suboptimal situation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh21023","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:20:40Z","timestamp":1630542040000},"page":"333-339","source":"Crossref","is-referenced-by-count":9,"title":["The challenge of diagnosis and treatment of neurosyphilis in China: results from a nationwide survey"],"prefix":"10.1071","volume":"18","author":[{"given":"Fang-Zhi","family":"Du","sequence":"first","affiliation":[{"name":"AInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College; National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing 210042, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-3826","authenticated-orcid":true,"given":"Qian-Qiu","family":"Wang","sequence":"additional","affiliation":[{"name":"AInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College; National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing 210042, China."},{"name":"CCorresponding authors. Q.-Q. Wang, email: wangqianqiunj@126.com; R.-L. Zhang, email: reallyvictor@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Ju","family":"Zheng","sequence":"additional","affiliation":[{"name":"AInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College; National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing 210042, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"AInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College; National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing 210042, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Jun","family":"Liang","sequence":"additional","affiliation":[{"name":"AInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College; National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing 210042, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"AInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College; National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing 210042, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"BDepartment of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China."},{"name":"CCorresponding authors. Q.-Q. Wang, email: wangqianqiunj@126.com; R.-L. 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