{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T15:52:06Z","timestamp":1773503526933,"version":"3.50.1"},"reference-count":6,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":987,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Syphilitic vasculitis (SV) is rare and difficult to be diagnosed. High-resolution vessel wall magnetic resonance imaging (HR-VWI) might be valuable in the diagnosis by differentiating SV from other vessel wall pathologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a rare case with severe isolated middle cerebral artery (MCA) stenosis and cerebral infarction, which was evaluated by serial HR-VWI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 46-year-old woman presented with an acute infarct in the left basal ganglia and severe isolated stenosis in left middle cerebral artery (MCA). Cerebrospinal fluid (CSF) analysis was performed and the findings were consistent with neurosyphilis diagnosis. The MCA stenosis was also suspected to be the result of SV. HR-VWI revealed the evidence of concentric thickening and circular uniform enhancement of the arterial wall. After two cycles of anti-syphilis treatment, subsequent HR-VWI showed that the MCA stenosis was reduced significantly except slight enhancement of the arterial wall, which confirmed that the SV caused the isolated MCA stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HR-VWI could be an important diagnostic tool for isolated middle cerebral artery stenosis caused by SV, which could serve as a biomarker for assessing the response to anti-syphilis treatment in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh22147","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T19:00:46Z","timestamp":1669921246000},"page":"80-82","source":"Crossref","is-referenced-by-count":4,"title":["Isolated middle cerebral artery stenosis caused by syphilitic vasculitis"],"prefix":"10.1071","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-675X","authenticated-orcid":true,"given":"Ping","family":"Zhang","sequence":"first","affiliation":[{"name":"ADepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"ADepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyue","family":"Chen","sequence":"additional","affiliation":[{"name":"BDepartment of Imaging, Changhai Hospital, Naval Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"ADepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"ADepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai 200433, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"issue":"1","key":"2025102615381165900_R1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06264-8","article-title":"Diagnostic tools for neurosyphilis: a systematic review.","volume":"21","author":"Boog","year":"2021","journal-title":"BMC Infect Dis"},{"issue":"8","key":"2025102615381165900_R2","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1007\/s00234-021-02891-9","article-title":"High-resolution MR vessel wall imaging in determining the stroke aetiology and risk stratification in isolated middle cerebral artery disease.","volume":"64","author":"Tandon","year":"2022","journal-title":"Neuroradiology"},{"key":"2025102615381165900_R3","doi-asserted-by":"publisher","first-page":"662.e13","DOI":"10.1016\/j.wneu.2015.10.085","article-title":"A singular case of neurosyphilis manifesting through a meningovascular chronic inflammatory process in association with the occurrence of two aneurysms involving the distal A2 segment of both anterior cerebral arteries: a case report and review of the literature.","volume":"87","author":"Bagatti","year":"2016","journal-title":"World Neurosurg"},{"issue":"5","key":"2025102615381165900_R4","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.neurol.2017.07.014","article-title":"Stroke and syphilis: a retrospective study of 53 patients.","volume":"174","author":"Ahbeddou","year":"2018","journal-title":"Rev Neurol (Paris)"},{"issue":"11","key":"2025102615381165900_R5","doi-asserted-by":"publisher","first-page":"3026","DOI":"10.1161\/STROKEAHA.117.018227","article-title":"Added value of vessel wall magnetic resonance imaging for differentiation of nonocclusive intracranial vasculopathies.","volume":"48","author":"Mossa-Basha","year":"2017","journal-title":"Stroke"},{"issue":"1","key":"2025102615381165900_R6","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00062-016-0529-9","article-title":"High-resolution vessel wall MRI: appearance of intravascular lymphoma mimics central nervous system vasculitis.","volume":"27","author":"Schaafsma","year":"2017","journal-title":"Clin Neuroradiol"}],"container-title":["Sexual Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/20\/1\/80\/692982\/sh22147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/20\/1\/80\/692982\/sh22147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:38:16Z","timestamp":1761507496000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/sh\/article\/20\/1\/80\/86524\/Isolated-middle-cerebral-artery-stenosis-caused-by"}},"subtitle":[],"editor":[{"given":"Somesh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,2]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2,7]]}},"URL":"https:\/\/doi.org\/10.1071\/sh22147","relation":{},"ISSN":["1448-5028","1449-8987"],"issn-type":[{"value":"1448-5028","type":"print"},{"value":"1449-8987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,2]]}}}