{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:32:08Z","timestamp":1782588728152,"version":"3.54.5"},"reference-count":12,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":874,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,7]]},"abstract":"\n Background<\/jats:title>\n Malignant syphilis is a rare manifestation of secondary syphilis and is commonly associated with human immunodeficiency virus coinfection. It can present with multiorgan involvement, which poses a diagnostic dilemma to clinicians.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We report a case of a middle aged male who presented with near complete vision loss in his right eye with initial concern for fungal endophthalmitis due to his injecting drug use history. He concurrently had right cheek and forearm ulcerative plaques.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n He was diagnosed with disseminated syphilis following the punch biopsy of his right cheek, with positive Treponema pallidum result on polymerase chain reaction and identification of spirochaetes on immunostaining from histopathology.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We present the epidemiology of syphilis in Australia and highlight the importance of testing for common sexually transmitted diseases within the emergence of the monkeypox outbreak.<\/jats:p>\n <\/jats:sec>","DOI":"10.1071\/sh22161","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T16:09:35Z","timestamp":1670861375000},"page":"83-86","source":"Crossref","is-referenced-by-count":2,"title":["Case report of a man with HIV presenting with malignant syphilis"],"prefix":"10.1071","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4282-414X","authenticated-orcid":true,"given":"Myong Gyu","family":"Kim","sequence":"first","affiliation":[{"name":"ASchool of Clinical Medicine, UNSW Sydney, Kensington, Sydney, NSW, Australia."},{"name":"BDepartment of Infectious Diseases, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasanth","family":"Kamath","sequence":"additional","affiliation":[{"name":"ASchool of Clinical Medicine, UNSW Sydney, Kensington, Sydney, NSW, Australia."},{"name":"CDepartment of Anatomical Pathology, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Martinello","sequence":"additional","affiliation":[{"name":"BDepartment of Infectious Diseases, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia."},{"name":"DKirby Institute, UNSW Sydney, Kensington, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Overton","sequence":"additional","affiliation":[{"name":"ASchool of Clinical Medicine, UNSW Sydney, Kensington, Sydney, NSW, Australia."},{"name":"BDepartment of Infectious Diseases, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"2025102419143882200_R1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0002-9343(88)90600-6","article-title":"Lues maligna in a patient with human immunodeficiency virus infection.","volume":"85","author":"Shulkin","year":"1988","journal-title":"Am J Med"},{"key":"2025102419143882200_R2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/OLQ.0b013e3181a2a946","article-title":"Lues maligna in early HIV infection case report and review of the literature.","volume":"36","author":"Tucker","year":"2009","journal-title":"Sex Transm Dis"},{"key":"2025102419143882200_R3","first-page":"119","article-title":"Noduloulcerative or \u201cmalignant\u201d syphilis occurring in an otherwise healthy woman: report and review of a dramatic dermatosis.","volume":"45","author":"Held","year":"1990","journal-title":"Cutis"},{"issue":"2","key":"2025102419143882200_R4","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/OLQ.0000000000000084","article-title":"Pathologically confirmed malignant syphilis using immunohistochemical staining: report of 3 cases and review of the literature.","volume":"41","author":"Cid","year":"2014","journal-title":"Sex Transm Dis"},{"issue":"1","key":"2025102419143882200_R5","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1136\/sti.2010.043042","article-title":"Ocular syphilis among HIV-infected patients: a systematic analysis of the 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meta-analysis.","volume":"2017","author":"Zhang","year":"2017","journal-title":"J Ophthalmol"},{"key":"2025102419143882200_R9","doi-asserted-by":"publisher","first-page":"e27931","DOI":"10.1002\/jmv.27931","article-title":"Epidemiological trends and clinical features of the ongoing monkeypox epidemic: a preliminary pooled data analysis and literature review.","volume":"95","author":"Bragazzi","year":"2022","journal-title":"J Med Virol"},{"issue":"1","key":"2025102419143882200_R10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s40471-018-0138-z","article-title":"An update on the global epidemiology of syphilis.","volume":"5","author":"Kojima","year":"2018","journal-title":"Curr Epidemiol Rep"},{"key":"2025102419143882200_R11"},{"key":"2025102419143882200_R12","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.737817","article-title":"The epidemic of sexually transmitted diseases under the influence of COVID-19 in China.","volume":"9","author":"Yan","year":"2021","journal-title":"Front Public Health"}],"container-title":["Sexual Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/20\/1\/83\/150080\/sh22161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/20\/1\/83\/150080\/sh22161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T23:14:44Z","timestamp":1761347684000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/sh\/article\/20\/1\/83\/21665\/Case-report-of-a-man-with-HIV-presenting-with"}},"subtitle":[],"editor":[{"given":"Ligang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2,7]]}},"URL":"https:\/\/doi.org\/10.1071\/sh22161","relation":{},"ISSN":["1448-5028","1449-8987"],"issn-type":[{"value":"1448-5028","type":"print"},{"value":"1449-8987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]}}}