{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:49:51Z","timestamp":1771606191982,"version":"3.50.1"},"reference-count":15,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":630,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"funder":[{"DOI":"10.13039\/100000002","name":"The U.S. National Institutes of Health","doi-asserted-by":"crossref","award":["U01AI069907"],"award-info":[{"award-number":["U01AI069907"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007554","name":"AIDS Life","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD073972"],"award-info":[{"award-number":["R01HD073972"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Females with perinatal HIV (PHIV) infection are at elevated risk for anogenital high-risk human papillomavirus (HR-HPV) infection. Limited data are available around the effect of the HPV vaccination after initiation of sexual activity among PHIV youth. This study aims to assess the impact of a bivalent HPV vaccination on the persistence of anogenital HR-HPV among sexually active female PHIV youth and matched HIV-negative controls aged 12\u201324\u00a0years in Thailand and Vietnam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>During a 3-year study, prevalent, incident, and persistent HR-HPV infection were assessed at annual visits. A subset of participants received a bivalent HPV vaccine. Samples were taken for HPV testing from the vagina, cervix, and anus. HR-HPV persistence was defined as the detection of the same genotype(s) at any anogenital compartment over\u00a0=\u00a0two consecutive visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 93 PHIV and 99 HIV-negative female youth enrolled in this study, 25 (27%) PHIV and 22 (22%) HIV-negative youth received a HPV vaccine. Persistent infection with any HR-HPV type was significantly lower among PHIV youth who received the vaccine compared to those who did not (33%\u00a0vs 61%, P\u00a0=\u00a00.02); a difference was not observed among HIV-negative youth (35%\u00a0vs 50%, P\u00a0=\u00a00.82). PHIV infection (adjusted prevalence ratio [aPR] 2.31, 95% CI 1.45\u20133.67) and not receiving a HPV vaccine (aPR, 1.19, 95%CI 1.06\u20131.33) were associated with persistent anogenital HR-HPV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bivalent HPV vaccination after initiation of sexual activity was associated with reduced persistence of anogenital HR-HPV infection in Southeast Asian PHIV female youth, which may be related to vaccine cross-protection. Primary and catch-up HPV vaccinations should be prioritised for children and youth with HIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh22185","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:07:45Z","timestamp":1700075265000},"source":"Crossref","is-referenced-by-count":4,"title":["The effects of bivalent human papillomavirus (HPV) vaccination on high-risk anogenital HPV infection among sexually active female adolescents with and without perinatally acquired HIV"],"prefix":"10.1071","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9005-2697","authenticated-orcid":true,"given":"Pradthana","family":"Ounchanum","sequence":"first","affiliation":[{"name":"AChiangrai Prachanukroh Hospital, Chiang Rai, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jullapong","family":"Achalapong","sequence":"additional","affiliation":[{"name":"AChiangrai Prachanukroh Hospital, Chiang Rai, 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