{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:36:33Z","timestamp":1784543793093,"version":"3.55.0"},"reference-count":12,"publisher":"CSIRO Publishing","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":662,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["CIFMS-2021-I2M-1-001"],"award-info":[{"award-number":["CIFMS-2021-I2M-1-001"]}]},{"name":"Wuxi Science and technology development funds","award":["N20192021"],"award-info":[{"award-number":["N20192021"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81772209"],"award-info":[{"award-number":["81772209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,11]]},"abstract":"<jats:p>We conducted a systematic review to analyse the consistency of nontreponemal-specific tests of Treponema pallidum in cerebrospinal fluid. We searched the PubMed, EMBASE, Web of Science, CNKI, Wanfang and Chongqing VIP databases. The inclusion criteria were studies conducted on nontreponemal-specific tests in cerebrospinal fluid (CSF) within the same population. Exclusion criteria were studies with incomplete data or where we were unable to obtain the full text, duplicate reports, case reports and studies without sensitivity or specificity results. We used kappa value analysis and McNemar\u2019s test to analyse study consistency. We initially collected a total of 198 articles and ultimately included six articles that involved 429 patients with neurosyphilis. The performance between venereal disease research laboratory tests (VDRL) and the reactive plasma regain or toluidine red serum unheated test was similar. The kappa value for consistency between VDRL and reactive plasma regain was &amp;gt;0.8 in three articles, and was 0.892 for consistency between VDRL and toluidine red serum unheated test in one article. Our results suggested that CSF-reactive plasma regain or CSF-toluidine red serum unheated test may serve as alternative tests in the diagnosis of neurosyphilis with CSF-VDRL.<\/jats:p>","DOI":"10.1071\/sh22203","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T21:16:11Z","timestamp":1689196571000},"page":"385-389","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of between-assay consistency among laboratory testing methods for neurosyphilis: a systematic review"],"prefix":"10.1071","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9373-5211","authenticated-orcid":true,"given":"Xu","family":"Zhang","sequence":"first","affiliation":[{"name":"AInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing 210042, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-5438","authenticated-orcid":true,"given":"Fang-Zhi","family":"Du","sequence":"additional","affiliation":[{"name":"AInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing 210042, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-3826","authenticated-orcid":true,"given":"Qian-Qiu","family":"Wang","sequence":"additional","affiliation":[{"name":"AInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing 210042, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7364-4649","authenticated-orcid":true,"given":"Rui-Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"BDepartment of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"issue":"14","key":"2025111812583042600_R1","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1056\/nejmra1906228","article-title":"Neurosyphilis.","volume":"381","author":"Ropper","year":"2019","journal-title":"N Engl J Med"},{"key":"2025111812583042600_R2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.35541\/cjd.20190808","article-title":"Guidelines for diagnosis and treatment of syphilis, gonorrhea and genital chlamydia trachomatis infections (2020).","volume":"53","author":"National Center for STD Control, Chinese Center for Disease Control and Prevention; Venereology Group, Chinese Society of Dermatology; Subcommittee on Venereology, China Dermatologist Association","year":"2020","journal-title":"Chin J Dermatol"},{"issue":"4","key":"2025111812583042600_R3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021.","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"issue":"1","key":"2025111812583042600_R4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/CMR.8.1.1","article-title":"Laboratory diagnosis and interpretation of tests for syphilis.","volume":"8","author":"Larsen","year":"1995","journal-title":"Clin Microbiol Rev"},{"issue":"10","key":"2025111812583042600_R5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00100-21","article-title":"The laboratory diagnosis of syphilis.","volume":"59","author":"Satyaputra","year":"2021","journal-title":"J Clin Microbiol"},{"issue":"2","key":"2025111812583042600_R6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1590\/0004-282x20180155","article-title":"A comparison of nontreponemal tests in cerebrospinal fluid for neurosyphilis diagnosis: equivalent detection of specific antibodies.","volume":"77","author":"Versiani","year":"2019","journal-title":"Arq Neuropsiquiatr"},{"issue":"3","key":"2025111812583042600_R7","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1128\/JCM.02522-13","article-title":"Comparison of the cerebrospinal fluid (CSF) toluidine red unheated serum test and the CSF rapid plasma reagin test with the CSF venereal disease research laboratory test for diagnosis of neurosyphilis among HIV-negative syphilis patients in China.","volume":"52","author":"Zhu","year":"2014","journal-title":"J Clin Microbiol"},{"issue":"4","key":"2025111812583042600_R8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/jcla.20254","article-title":"Nontreponemal tests in the diagnosis of neurosyphilis: an evaluation of the Venereal Disease Research Laboratory (VDRL) and the Rapid Plasma Reagin (RPR) tests.","volume":"22","author":"Castro","year":"2008","journal-title":"J Clin Lab Anal"},{"issue":"6","key":"2025111812583042600_R9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1097\/OLQ.0b013e31824b1cde","article-title":"The rapid plasma reagin test cannot replace the venereal disease research laboratory test for neurosyphilis diagnosis.","volume":"39","author":"Marra","year":"2012","journal-title":"Sex Transm Dis"},{"issue":"2","key":"2025111812583042600_R10","first-page":"127","article-title":"Comparisons of several laboratory tests in the diagnosis of neurosyphilis.","volume":"44","author":"Lin","year":"2011","journal-title":"Chin J Dermatol"},{"issue":"3","key":"2025111812583042600_R11","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/OLQ.0b013e3181f42093","article-title":"The usefulness of toluidine red unheated serum test in the diagnosis of HIV-negative neurosyphilis.","volume":"38","author":"Jiang","year":"2011","journal-title":"Sex Transm Dis"},{"issue":"2","key":"2025111812583042600_R12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002204","article-title":"Comparing the performance characteristics of CSF-TRUST and CSF-VDRL for syphilis: a cross-sectional study.","volume":"3","author":"Gu","year":"2013","journal-title":"BMJ Open"}],"container-title":["Sexual Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/20\/5\/385%20\/150106\/sh22203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/20\/5\/385%20\/150106\/sh22203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T17:58:37Z","timestamp":1763488717000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/sh\/article\/20\/5\/385%20\/21671\/Evaluation-of-between-assay-consistency-among"}},"subtitle":[],"editor":[{"given":"Somesh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10,11]]}},"URL":"https:\/\/doi.org\/10.1071\/sh22203","relation":{},"ISSN":["1448-5028","1449-8987"],"issn-type":[{"value":"1448-5028","type":"print"},{"value":"1449-8987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,13]]}}}