{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:27:14Z","timestamp":1781047634969,"version":"3.54.1"},"reference-count":24,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":683,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"funder":[{"name":"Science and Technology Project of Suzhou Health and Family Planning Commission","award":["LCZX201818"],"award-info":[{"award-number":["LCZX201818"]}]},{"name":"Suzhou Clinical Medical Expert Team Introduction Project","award":["SZYJTD201811"],"award-info":[{"award-number":["SZYJTD201811"]}]},{"name":"Suzhou Science and Technology Plan Project","award":["SKJY2021137"],"award-info":[{"award-number":["SKJY2021137"]}]},{"name":"Suzhou Science and Education Revitalizing Health Youth Science and Technology Project","award":["KJXW2021052"],"award-info":[{"award-number":["KJXW2021052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>China is one of the countries that set the goal to eliminate mother-to-child transmission (EMTCT) of syphilis by a target date. Active screening for syphilis among pregnant women, followed by effective treatment of maternal syphilis, is critical for achieving the goal. The China health authority issued national implementation protocols to guide EMTCT practice in health facilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Within a cohort of infants born to mothers infected with syphilis, we obtained the data of regimens used for treatment of maternal syphilis from the National Information System of Prevention of Mother-to-Child Transmission of HIV, Syphilis and Hepatitis B, and analysed the physician\u2019s treatment behaviour and its associated factors in a public hospital in Suzhou of China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 450 pregnant women who were positive for treponemal or non-treponemal antibody, or had previous infection with syphilis were included into the study for analysis. Of them, 260 (57.8%) were positive for both treponemal and non-treponemal antibodies (syphilis seropositivity), and 353 (78.4%) were treated for syphilis according to the protocol in which 123 (34.8%) were treated with two courses. Non-adherence to treatment recommended by the protocol for maternal syphilis was significantly associated with antenatal visits in the third trimester (AOR 6.65, 95% CI 2.20\u201320.07, P\u00a0=\u00a00.001), being positive only for a treponemal test (AOR 5.34, 95% CI 3.07\u20139.29, P\u00a0&amp;lt;\u00a00.001) or having a syphilis infection before the pregnancy (AOR 2.05, 95% CI 1.14\u20133.69, P\u00a0=\u00a00.017), whereas the uptake of treatment for two treatment courses was associated with attending antenatal care in 2020 or before (AOR 3.49, 95% CI 1.89\u20136.42, P\u00a0&amp;lt;\u00a00.001), being positive for treponemal and non-treponemal tests (AOR 5.28, 95% CI 2.78\u201310.06, P\u00a0&amp;lt;\u00a00.001) or having non-treponemal antibody titre of =1:8 (AOR 3.71, 95% CI 1.77\u20137.78, P\u00a0=\u00a00.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Implementation of the current recommendation to offer a universal treatment for syphilis among all pregnant women who are shown to be positive for a treponemal test alone is challenging in some clinical settings in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh23082","type":"journal-article","created":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:01:55Z","timestamp":1696190515000},"page":"523-530","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of maternal syphilis for preventing congenital syphilis: an observational study of adherence to treatment recommendation in Suzhou, China, 2019\u20132021"],"prefix":"10.1071","volume":"20","author":[{"given":"Xing-Fan","family":"Mo","sequence":"first","affiliation":[{"name":"ADepartment of Dermatology, The Fifth People\u2019s Hospital of Suzhou, Suzhou, China."},{"name":"BDepartment of Dermatology, The Affiliated Hospital of Infectious Diseases of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Zhi","family":"Feng","sequence":"additional","affiliation":[{"name":"ADepartment of Dermatology, The Fifth People\u2019s Hospital of Suzhou, Suzhou, China."},{"name":"BDepartment of Dermatology, The Affiliated Hospital of Infectious Diseases of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0789-8816","authenticated-orcid":true,"given":"Ting-Ting","family":"Jiang","sequence":"additional","affiliation":[{"name":"CInstitute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China."},{"name":"DNational Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"ADepartment of Dermatology, The Fifth People\u2019s Hospital of Suzhou, Suzhou, China."},{"name":"BDepartment of Dermatology, The Affiliated Hospital of Infectious Diseases of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Juan","family":"Wu","sequence":"additional","affiliation":[{"name":"ADepartment of Dermatology, The Fifth People\u2019s Hospital of Suzhou, Suzhou, China."},{"name":"BDepartment of Dermatology, The Affiliated Hospital of Infectious Diseases of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Li","sequence":"additional","affiliation":[{"name":"ADepartment of Dermatology, The Fifth People\u2019s Hospital of Suzhou, Suzhou, China."},{"name":"BDepartment of Dermatology, The Affiliated Hospital of Infectious Diseases of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8727-448X","authenticated-orcid":true,"given":"Min-Zhi","family":"Wu","sequence":"additional","affiliation":[{"name":"ADepartment of Dermatology, The Fifth People\u2019s Hospital of Suzhou, Suzhou, China."},{"name":"BDepartment of Dermatology, The Affiliated Hospital of Infectious Diseases of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Ping","family":"Yin","sequence":"additional","affiliation":[{"name":"CInstitute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China."},{"name":"DNational Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3927-2065","authenticated-orcid":true,"given":"Xiang-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"CInstitute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China."},{"name":"DNational Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"2025102615393317500_R1"},{"key":"2025102615393317500_R2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001396","article-title":"Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data.","volume":"10","author":"Newman","year":"2013","journal-title":"PLoS Med"},{"key":"2025102615393317500_R3","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/S1473-3099(11)70104-9","article-title":"Effectiveness of interventions to improve screening for syphilis in pregnancy: a systematic review and meta-analysis.","volume":"11","author":"Hawkes","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"2025102615393317500_R4","doi-asserted-by":"publisher","first-page":"e102203","DOI":"10.1371\/journal.pone.0102203","article-title":"Reported estimates of adverse pregnancy outcomes among women with and without syphilis: a systematic review and meta-analysis.","volume":"9","author":"Qin","year":"2014","journal-title":"PLoS One"},{"key":"2025102615393317500_R5","unstructured":"WHO. The global elimination of congenital syphilis: rationale and strategy for action. Geneva: World Health Organization; 2007. Available at https:\/\/www.who.int\/publications\/i\/item\/9789241595858 [accessed 19 October 2022]"},{"key":"2025102615393317500_R6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211720","article-title":"Global burden of maternal and congenital syphilis and associated adverse birth outcomes \u2013 estimates for 2016 and progress since 2012.","volume":"14","author":"Korenromp","year":"2019","journal-title":"PLoS ONE"},{"key":"2025102615393317500_R7","unstructured":"China NHFPC. Notice of the General Office of the National Health and Family Planning Commission on comprehensively carrying out the prevention of mother-to-child transmission of AIDS, syphilis and hepatitis B (in Chinese). Beijing: National Health and Family Planning Commission of the People\u2019s Republic of China; 2015. Available at http:\/\/www.nhc.gov.cn\/fys\/s3581\/201506\/4f2123fa955a44afa75a75da2ad35d6e.shtml [accessed 19 October 2022]"},{"key":"2025102615393317500_R8","unstructured":"China NHC. Announcement on the Public Solicitation of Comments on the Work Specification for the Prevention of Mother-to-Child Transmission of HIV\/AIDS, Syphilis and Hepatitis B (2020 Edition) (Draft for Comments) (in Chinese). Beijing: National Health Commission of the People\u2019s Republic of China; 2020. Available at http:\/\/www.nhc.gov.cn\/fys\/s3582\/202007\/ba48eea5e52f4fb1b73b066fddd47015.shtml [accessed 19 October 2022]"},{"key":"2025102615393317500_R9"},{"key":"2025102615393317500_R10"},{"key":"2025102615393317500_R11","first-page":"693","article-title":"Estimation of syphilis epidemic through application of workbook method among populations aged from 15 to 49 years old in China in 2011 (in Chinese).","volume":"48","author":"Jiang","year":"2014","journal-title":"Chin J Prev Med"},{"key":"2025102615393317500_R12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/JD9.0000000000000134","article-title":"The past 70 years in control of syphilis in China: elimination and responses to resurgence.","volume":"3","author":"Chen","year":"2020","journal-title":"Int J Dermato Venereo"},{"issue":"8","key":"2025102615393317500_R13","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/S1473-3099(17)30327-4","article-title":"Challenges in responses to syphilis epidemic.","volume":"17","author":"Chen","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2025102615393317500_R14","unstructured":"World Health Organization. Global guidance on criteria and processes for validation: elimination of mother-to-child transmission of HIV, syphilis and hepatitis B virus. Geneva: WHO; 2022. Available at https:\/\/www.who.int\/publications\/i\/item\/9789240039360 [accessed 19 October 2022]"},{"key":"2025102615393317500_R15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021.","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"key":"2025102615393317500_R16","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1177\/0956462415624059","article-title":"UK national guidelines on the management of syphilis 2015.","volume":"27","author":"Kingston","year":"2016","journal-title":"Int J STD AIDS"},{"key":"2025102615393317500_R17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1055\/s-0038-1676569","article-title":"Syphilis in pregnancy: the reality in a public hospital.","volume":"41","author":"Torres","year":"2019","journal-title":"Rev Bras Ginecol Obstet"},{"key":"2025102615393317500_R18","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1093\/cid\/cix371","article-title":"Risk of congenital syphilis (CS) following treatment of maternal syphilis: results of a CS control program in China.","volume":"65","author":"Hong","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2025102615393317500_R19","unstructured":"Srikantiah P. Elimination of new paediatric HIV infections and congenital syphilis in Asia-Pacific, 2011\u20132015: conceptual framework & monitoring and evaluation guide. Bangkok: UNICEF East Asia and Pacific Regional Office; 2011. Available at https:\/\/static.wixstatic.com\/ugd\/98aff9_cf1fc461b8fd475e84ed99c1e9633e95.pdf [accessed 19 October 2022]"},{"key":"2025102615393317500_R20","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1136\/sti.71.2.68","article-title":"Seroreversion of the serological tests for syphilis in the newborns born to treated syphilitic mothers.","volume":"71","author":"Chang","year":"1995","journal-title":"Sex Transm Infect"},{"key":"2025102615393317500_R21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1136\/sti.66.3.159","article-title":"Syphilis intervention in pregnancy: Zambian demonstration project.","volume":"66","author":"Hira","year":"1990","journal-title":"Sex Transm Infect"},{"key":"2025102615393317500_R22","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1086\/342952","article-title":"Syphilis in pregnancy in Tanzania. I. Impact of maternal syphilis on outcome of pregnancy.","volume":"186","author":"Watson-Jones","year":"2002","journal-title":"J Infect Dis"},{"key":"2025102615393317500_R23","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2471\/BLT.12.107623","article-title":"Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis.","volume":"91","author":"Gomez","year":"2013","journal-title":"Bull World Health Organ"},{"key":"2025102615393317500_R24","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1097\/OLQ.0000000000000819","article-title":"Nonadherence to national guidelines for antibiotic treatment of uncomplicated gonorrhea in China: results from a nationwide survey.","volume":"45","author":"Han","year":"2018","journal-title":"Sex Transm Dis"}],"container-title":["Sexual Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/20\/6\/523\/693225\/sh23082.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/20\/6\/523\/693225\/sh23082.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:39:41Z","timestamp":1761507581000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/sh\/article\/20\/6\/523\/86571\/Treatment-of-maternal-syphilis-for-preventing"}},"subtitle":[],"editor":[{"given":"Matthew","family":"Hogben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12,12]]}},"URL":"https:\/\/doi.org\/10.1071\/sh23082","relation":{},"ISSN":["1448-5028","1449-8987"],"issn-type":[{"value":"1448-5028","type":"print"},{"value":"1449-8987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]}}}