{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:24:49Z","timestamp":1774610689742,"version":"3.50.1"},"reference-count":66,"publisher":"CSIRO Publishing","issue":"3","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":443,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,4]]},"abstract":"<jats:p>Syphilis remains a pressing public health concern with potential severe morbidity if left untreated. To improve syphilis screening, targeted interventions are crucial, especially in at-risk populations. This systematic review synthesises studies that compare syphilis screening in the presence and absence of an intervention. A systematic search of four databases was conducted (Medline, Embase, Cinahl and Scopus). The primary outcomes evaluated included syphilis screening, re-screening and detection rates. Findings were synthesised narratively. Where multiple studies were clinically heterogenous, a pooled odds ratio was calculated. Twenty-four studies were included. A variety of interventions showed promise including clinician alerts, which increased syphilis screening rate (OR range, 1.25\u20131.45) and patient SMS reminders that mostly improved re-screening\/re-attendance rates (OR range, 0.93\u20134.4). Coupling syphilis serology with routine HIV monitoring increased the proportion of HIV-positive individuals undergoing both tests. However, pooling three studies with this intervention using the outcome of syphilis detection rate yielded inconclusive results (pooled OR 1.722 [95% CI 0.721\u20132.723], I2\u00a0=\u00a024.8%, P\u00a0=\u00a00.264). The introduction of hospital-based packaged testing for screening high-risk individuals is unique given hospitals are not typical locations for public health initiatives. Nurse-led clinics and clinician incentives were successful strategies. Including syphilis screening with other existing programs has potential to increase screening rates (OR range, 1.06\u20132.08), but requires further investigation. Technology-driven interventions produced cost-effective, feasible and positive outcomes. Challenges were evident in achieving guideline-recommended screening frequencies for men who have sex with men, indicating the need for multifaceted approaches. Wider application of these interventions may improve syphilis screening and detection rates.<\/jats:p>","DOI":"10.1071\/sh24019","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T19:31:33Z","timestamp":1716233493000},"source":"Crossref","is-referenced-by-count":2,"title":["Interventions aimed at increasing syphilis screening among non-pregnant individuals in healthcare settings: a systematic review and meta-analysis"],"prefix":"10.1071","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7671-6808","authenticated-orcid":true,"given":"Leah","family":"Moncrieff","sequence":"first","affiliation":[{"name":"ACollege of Medicine and Dentistry, James Cook University, Building K Level 1, 475 Bridge Road, Mackay, Qld 4740, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"ACollege of Medicine and Dentistry, James Cook University, Building K Level 1, 475 Bridge Road, Mackay, Qld 4740, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Hall","sequence":"additional","affiliation":[{"name":"ACollege of Medicine and Dentistry, James Cook University, Building K Level 1, 475 Bridge Road, Mackay, Qld 4740, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Heal","sequence":"additional","affiliation":[{"name":"ACollege of Medicine and Dentistry, James Cook University, Building K Level 1, 475 Bridge Road, Mackay, Qld 4740, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"2025102615344243400_R1","unstructured":"Tudor ME, Al Aboud AM, Lesie SW, et al. 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