{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:38:22Z","timestamp":1792183102242,"version":"4.4.0"},"reference-count":31,"publisher":"CSIRO Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex. Health"],"accepted":{"date-parts":[[2025,5,8]]},"abstract":"<jats:p>Background   Doxycycline post-exposure prophylaxis (doxy-PEP) has shown efficacy in preventing bacterial sexually transmitted infections (STIs) among men who have sex with men (MSM). We aimed to investigate the awareness and willingness toward doxy-PEP among MSM in the real-world setting.     Methods   From October 2023 to March 2024, we enrolled MSM aged \u226518\u00a0years, including people with HIV and PrEP users in Taiwan. Participants completed a questionnaire interview on sexual behaviors, STI history, and awareness and willingness to use doxy-PEP. Factors associated with willingness and doxy-PEP prescription were identified.     Results   Of 1100 participants (median age, 36\u00a0years), 75.5% were people with HIV and 24.5% were PrEP users. Among them, 29.8% (328\/1100) had heard of doxy-PEP. After education and counseling, 85.9% (945\/1100) expressed willingness to use doxy-PEP and 45.6% (431\/945) received prescriptions for doxy-PEP. In multivariable analysis, willingness to use doxy-PEP was associated with engaging in anal sex (AOR\u00a02.98, 95% CI\u00a01.01\u20138.78), having fixed sexual partners (AOR\u00a00.53, 95% CI\u00a00.34\u20130.82), using recreational drugs (AOR\u00a01.59, 95% CI\u00a01.01\u20132.50) and receiving suggestions from healthcare providers (AOR\u00a01.89, 95% CI\u00a01.22\u20132.91). Starting doxy-PEP was associated with having a bachelor\u2019s degree or higher (AOR\u00a01.47, 95% CI\u00a01.03\u20132.09), more than five sexual partners (AOR\u00a01.97, 95% CI\u00a01.18\u20133.27), chlamydia history (AOR\u00a01.92, 95% CI\u00a01.23\u20132.99), suggestions from healthcare providers (AOR 1.64, 95% CI\u00a01.10\u20132.45) and information from scientific research papers (AOR\u00a01.34, 95% CI\u00a01.01\u20131.79).     Conclusions   MSM in Taiwan had high willingness toward doxy-PEP, which was correlated with their at-risk sexual behavior. Understanding factors influencing willingness and counseling from healthcare providers may guide doxy-PEP implementation.<\/jats:p>","DOI":"10.1071\/sh24136","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T21:09:12Z","timestamp":1748207352000},"source":"Crossref","is-referenced-by-count":8,"title":["Awareness and willingness toward doxycycline post-exposure prophylaxis use for bacterial sexually transmitted infections among men who have sex with men"],"prefix":"10.1071","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6734-1593","authenticated-orcid":true,"given":"Yi-Ting","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Yin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Shan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Da","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chung","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Hsien","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hsi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Hsiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristine","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Huei","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-Min","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Ching","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Un-In","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Yow","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Zhen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi-Yen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-6595","authenticated-orcid":true,"given":"Ling-Ya","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Ting","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guei-Chi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-0836","authenticated-orcid":true,"given":"Chien-Ching","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"issue":"4","key":"SH24136R1","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S1473-3099(21)00448-5","article-title":"Global burden and trends of sexually transmitted infections from 1990 to 2019: an observational trend study.","volume":"22","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"SH24136R2","unstructured":"WHO. Global progress report on HIV, viral hepatitis and sexually transmitted infections. WHO; 2021. 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A snapshot survey on doxycycline use for prevention of sexually transmitted infections in parts of the German MSM community.","volume":"51","year":"2023","journal-title":"Infection"},{"issue":"6","key":"SH24136R18","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1136\/sextrans-2020-054592","article-title":"Factors associated with reporting antibiotic use as STI prophylaxis among HIV PrEP users: findings from a cross-sectional online community survey, May-July 2019, UK.","volume":"97","year":"2021","journal-title":"Sex Transm Infect"},{"key":"SH24136R19","unstructured":"Taiwan AIDS Society. Guidelines for diagnosis and treatment of HIV\/AIDS. 2020. 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