{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T10:16:21Z","timestamp":1781345781344,"version":"3.54.1"},"reference-count":56,"publisher":"CSIRO Publishing","issue":"3","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":107,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Epidemiology modelling and risk assessment","award":["20200344"],"award-info":[{"award-number":["20200344"]}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"publisher","award":["2022YFC2304900, 2022YFC2505100"],"award-info":[{"award-number":["2022YFC2304900, 2022YFC2505100"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2505100, 2022YFC2505103"],"award-info":[{"award-number":["2022YFC2505100, 2022YFC2505103"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1193955"],"award-info":[{"award-number":["1193955"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Outstanding Young Scholars Support Program","award":["3111500001"],"award-info":[{"award-number":["3111500001"]}]},{"name":"Xi\u2019an Jiaotong University Young Scholar Support Grant","award":["YX6J004"],"award-info":[{"award-number":["YX6J004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pre-exposure prophylaxis (PrEP) uptake remains low in mainland China and Hong Kong. We examined preferences for different PrEP modalities among men who have sex with men (MSM) in mainland China and Hong Kong.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional online survey from May to November 2022 in mainland China and Hong Kong. Eligible participants were aged \u226518\u00a0years, identified as MSM and self-reported HIV-negative, or unknown HIV status. Random forest models and SHapley Additive exPlanations analyses were used to identify key factors influencing preferences for and willingness to use six PrEP options: (1) daily oral, (2) on-demand oral, (3) monthly oral, (4) two-monthly injectable, (5) six-monthly injectable, and (6) implantable PrEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 2142 participants (mainland China: 1604; Hong Kong: 538), the mean age was 28.4 (\u00b17.0) years in mainland China and 34.7 (\u00b19.5) years in Hong Kong. Current PrEP use was similar between mainland China and Hong Kong (18.0% vs 17.8%, P\u00a0=\u00a00.93), with an additional 10.5% and 8.0% reporting past PrEP use (P\u00a0=\u00a00.11), respectively. A greater proportion of participants from mainland China preferred on-demand PrEP compared to those from Hong Kong (55.7% vs 48.1%, P\u00a0&amp;lt;\u00a00.01), whereas more participants from Hong Kong preferred monthly oral PrEP (53.2% vs 47.3%, P\u00a0=\u00a00.02). Willingness to use non-oral options was lower, with two-monthly injectable PrEP preferred by 21.1% (19.1\u201323.1%) in mainland China and 15.4% (12.3\u201318.5%) in Hong Kong (P\u00a0&amp;lt;\u00a00.01). Among Hong Kong participants, condom use frequency and migration status were important predictors of willingness to use both oral and injectable PrEP options. Current PrEP use status and PrEP attitudes were consistently important predictors. Additionally, individuals who preferred six-monthly injectable PrEP tended to dislike the two-monthly option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>On-demand and monthly PrEP options remain the preferred choices, though the monthly oral option is neither proven nor available. However, the factors influencing these preferences vary, highlighting the need for tailored and targeted approaches to PrEP implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh24247","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T21:12:50Z","timestamp":1748207570000},"source":"Crossref","is-referenced-by-count":3,"title":["Preferences and willingness to use pre-exposure prophylaxis for HIV among men who have sex with men in mainland China and Hong Kong"],"prefix":"10.1071","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5529-6660","authenticated-orcid":true,"given":"Jiajun","family":"Sun","sequence":"first","affiliation":[{"name":"ASchool of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Vic, Australia."},{"name":"BMelbourne Sexual Health Centre, Alfred Health, Melbourne, Vic, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-7403","authenticated-orcid":true,"given":"Jason J.","family":"Ong","sequence":"additional","affiliation":[{"name":"ASchool of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Vic, Australia."},{"name":"BMelbourne Sexual Health Centre, Alfred Health, Melbourne, Vic, Australia."},{"name":"CFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-6407","authenticated-orcid":true,"given":"Heather-Marie","family":"Schmidt","sequence":"additional","affiliation":[{"name":"DJoint United Nations Programme on HIV\/AIDS (UNAIDS), Geneva, Switzerland."},{"name":"EWorld Health Organization, Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-1011","authenticated-orcid":true,"given":"Curtis","family":"Chan","sequence":"additional","affiliation":[{"name":"FKirby Institute, University of New South Wales, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-8278","authenticated-orcid":true,"given":"Benjamin R.","family":"Bavinton","sequence":"additional","affiliation":[{"name":"FKirby Institute, University of New South Wales, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-8480","authenticated-orcid":true,"given":"Kimberly Elizabeth","family":"Green","sequence":"additional","affiliation":[{"name":"GPATH, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0036-3165","authenticated-orcid":true,"given":"Nittaya","family":"Phanuphak","sequence":"additional","affiliation":[{"name":"HInstitute of HIV Research and Innovation (IHRI), Bangkok, Thailand."},{"name":"ICentre of Excellence in Transgender Health (CETH), Chulalongkorn University, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midnight","family":"Poonkasetwattana","sequence":"additional","affiliation":[{"name":"JAsia Pacific Coalition on Male Sexual Health (APCOM), Bangkok, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Suwandi","sequence":"additional","affiliation":[{"name":"KAsia Pacific Transgender Network, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Fraser","sequence":"additional","affiliation":[{"name":"FKirby Institute, University of New South Wales, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-707X","authenticated-orcid":true,"given":"Weiming","family":"Tang","sequence":"additional","affiliation":[{"name":"LThe University of North Carolina at Chapel Hill Project-China, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cassell","sequence":"additional","affiliation":[{"name":"MFamily Health International (FHI) 360, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Boonyapisomparn","sequence":"additional","affiliation":[{"name":"KAsia Pacific Transgender Network, Bangkok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9062-3540","authenticated-orcid":true,"given":"Edmond Pui Hang","family":"Choi","sequence":"additional","affiliation":[{"name":"NSchool of Nursing, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-084X","authenticated-orcid":true,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"ASchool of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Vic, Australia."},{"name":"BMelbourne Sexual Health Centre, Alfred Health, Melbourne, Vic, Australia."},{"name":"OChina-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, Shaanxi, China."},{"name":"PPhase I Clinical trial research ward, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warittha","family":"Tieosapjaroen","sequence":"additional","affiliation":[{"name":"ASchool of Translational Medicine, Faculty of 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