{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T22:28:52Z","timestamp":1763504932306,"version":"3.45.0"},"reference-count":36,"publisher":"CSIRO Publishing","issue":"4","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":152,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2371367, 82172331, 82001600, 81871729"],"award-info":[{"award-number":["2371367, 82172331, 82001600, 81871729"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fujian Provincial Natural Science Foundation of China","award":["2024D023"],"award-info":[{"award-number":["2024D023"]}]},{"DOI":"10.13039\/501100017686","name":"Fujian provincial health technology project","doi-asserted-by":"crossref","award":["2024ZD01008"],"award-info":[{"award-number":["2024ZD01008"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Relying simply on the stage of latent syphilis may lead to excessive treatment strategies. Utilizing nontreponemal immunoglobulin M (IgM) antibodies to assess syphilis activity and tailor treatment strategies may offer enhanced therapeutic advantages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate whether nontreponemal IgM antibodies can serve as a serological marker for assessing the activity of latent syphilis and inform personalized treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated nontreponemal IgM antibodies in 412 latent syphilis patients and conducted a 2-year follow up to analyze their rate of seroconversion (the change from seropositive to seronegative status), to evaluate whether nontreponemal IgM antibodies could assess the activity of latent syphilis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The positive nontreponemal IgM group demonstrated a lower seroconversion rate (P\u00a0=\u00a00.0178) and achieved seroconversion slower compared with the negative group (hazard ratio: 0.386). Early-stage patients exhibited higher nontreponemal IgM antibody levels (P\u00a0&amp;lt;\u00a00.0001) and lower seroconversion rates (P\u00a0=\u00a00.018) than late-stage patients. Elderly patients showed lower nontreponemal IgM antibody levels (P\u00a0&amp;lt;\u00a00.0001) and higher seroconversion rates (P\u00a0=\u00a00.0022) than non-elderly patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Latent syphilis patients with positive nontreponemal IgM require a longer time to seroconversion and exhibit a lower seroreversion rate, indicating their higher syphilis activity. Nontreponemal IgM antibodies can serve as a serological marker for detecting syphilis activity in latent syphilis. It is recommended to test for nontreponemal IgM antibodies before treatment to identify syphilis activity for personalized treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh25047","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T19:50:02Z","timestamp":1750276202000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring syphilis activity for personalized treatment strategies in latent syphilis: a 2-year cohort study"],"prefix":"10.1071","volume":"22","author":[{"given":"Jia-Wen","family":"Xie","sequence":"first","affiliation":[{"name":"ACenter of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, China."},{"name":"BInstitute of Infectious Disease, School of Medicine, Xiamen University, Xiamen, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Wen","family":"Zheng","sequence":"additional","affiliation":[{"name":"ACenter of Clinical 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