{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:01:46Z","timestamp":1784775706284,"version":"3.55.0"},"reference-count":28,"publisher":"CSIRO Publishing","issue":"4","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,17]]},"abstract":"\n Background<\/jats:title>\n Oral HIV pre-exposure prophylaxis (PrEP) uptake in the Asia-Pacific region is sub-optimal with only 2% of the 2025 goal of PrEP use achieved in 2023. There is no agreed-on measure of unmet PrEP need, and no assessment of unmet need across the Asia-Pacific.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We surveyed men who have sex with men (MSM) and transgender women (TGW) in 15 Asian countries and Australia (16 total). We defined unmet PrEP need as those who had: (1) heard of and wanted to take PrEP, but never taken it; (2) never heard of PrEP but had HIV risk factors; (3) taken oral PrEP but preferred a different PrEP product; or (4) temporarily discontinued oral PrEP due to a barrier. Descriptive statistics and multivariable logistic regression models identifed factors associated with unmet PrEP need<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 17,032 MSM and 1260 TGW surveyed, 59.9% MSM and 47.5% TGW had unmet PrEP need. The most common unmet PrEP need was being PrEP-nai\u0308ve but wanting to take PrEP (55.6% MSM; 31.2% TGW), followed by being a current oral PrEP user but preferring to use a different product (18.2% MSM; 28.1% TGW), being unaware of PrEP but reporting risk factors indicative of PrEP need (12.4% MSM; 20.7% TGW), and temporarily discontinued PrEP due to a barrier to accessing services (13.8% MSM;\u00a0and 19.9% TGW).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Unmet need is a critical measure of PrEP access, uptake, and coverage. Unmet PrEP need in Asia-Pacific is exacerbated by funding cuts from international donors. Urgent action is needed to increase PrEP access to achieve its goal of ending HIV by 2030.<\/jats:p>\n <\/jats:sec>","DOI":"10.1071\/sh25072","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:21:41Z","timestamp":1784773301000},"source":"Crossref","is-referenced-by-count":0,"title":["Just how far off target are we? Measuring unmet pre-exposure prophylaxis need among men who have sex with men and transgender women in Asia-Pacific"],"prefix":"10.1071","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-8480","authenticated-orcid":true,"given":"Kimberly E.","family":"Green","sequence":"first","affiliation":[{"name":"APATH, Hanoi, Viet Nam. Email: kgreen@path.org"},{"name":"BHarvard University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-8278","authenticated-orcid":true,"given":"Benjamin R.","family":"Bavinton","sequence":"additional","affiliation":[{"name":"CKirby Institute, UNSW Sydney, Sydney, NSW, Australia. Email: bbavinton@kirby.unsw.edu.au"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0036-3165","authenticated-orcid":true,"given":"Nittaya","family":"Phanuphak","sequence":"additional","affiliation":[{"name":"DInstitute for HIV Research and Innovation, Bangkok, Thailand. Email: nittaya.p@ihri.org"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-6407","authenticated-orcid":true,"given":"Heather-Marie A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"EUNAIDS, Geneva, Switzerland. Email: schmidth@unaids.org"},{"name":"FWorld Health Organization, Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-9262","authenticated-orcid":true,"given":"Warittha","family":"Tieosapjaroen","sequence":"additional","affiliation":[{"name":"GMelbourne Sexual Health Centre, Alfred Health, Melbourne, Vic, Australia. Email: wtieosapjaroen@mshc.org.au, lei.zhang1@monash.edu, Jong@mshc.org.au"},{"name":"HSchool of Translational Medicine, Monash University, Melbourne, Vic, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Cassell","sequence":"additional","affiliation":[{"name":"IFHI360, Atlanta, GA, USA. Email: mcassell@mac.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-084X","authenticated-orcid":true,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"GMelbourne Sexual Health Centre, Alfred Health, Melbourne, Vic, Australia. Email: wtieosapjaroen@mshc.org.au, lei.zhang1@monash.edu, Jong@mshc.org.au"},{"name":"HSchool of Translational Medicine, Monash University, Melbourne, Vic, Australia."},{"name":"JChina-Australia Joint Research Centre for Infectious Diseases, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, Shaanxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-7403","authenticated-orcid":true,"given":"Jason J.","family":"Ong","sequence":"additional","affiliation":[{"name":"GMelbourne Sexual Health Centre, Alfred Health, Melbourne, Vic, Australia. Email: wtieosapjaroen@mshc.org.au, lei.zhang1@monash.edu, Jong@mshc.org.au"},{"name":"HSchool of Translational Medicine, Monash University, Melbourne, Vic, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midnight","family":"Poonkasetwattana","sequence":"additional","affiliation":[{"name":"KAPCOM, Bangkok, Thailand. Email: midnightp@apcom.org, suwandin@apcom.org"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Boonyapisomparn","sequence":"additional","affiliation":[{"name":"LSisters Foundation, Pattaya, Thailand. Email: huab2007@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Suwandi","sequence":"additional","affiliation":[{"name":"KAPCOM, Bangkok, Thailand. Email: midnightp@apcom.org, suwandin@apcom.org"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-1011","authenticated-orcid":true,"given":"Curtis","family":"Chan","sequence":"additional","affiliation":[{"name":"CKirby Institute, UNSW Sydney, Sydney, NSW, Australia. Email: bbavinton@kirby.unsw.edu.au"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026072222213802000_R1","unstructured":"UNAIDS. 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Differentiated PrEP delivery \u2013 from pilots to pushing towards the global PrEP targets. Pivoting HIV prevention during a parallel pandemic. 11th IAS Conference on HIV Science, Berlin; 2021. Geneva: International AIDS Society."},{"key":"2026072222213802000_R11","unstructured":"World Health Organization. Differentiated and simplified pre-exposure prophylaxis for HIV prevention: update to WHO implementation guidance; 2022. Geneva: WHO. Available at https:\/\/www.who.int\/publications\/i\/item\/9789240053694"},{"key":"2026072222213802000_R12","first-page":"7","article-title":"Unmet need as an indicator of health care access.","volume":"15","author":"Allin","year":"2009","journal-title":"Eurohealth"},{"key":"2026072222213802000_R13","unstructured":"Bradley SEK, Croft TN, Fishel JD, Westoff CF. Revising unmet need for family planning. DHS Analytical Studies No. 25. 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