{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T04:42:45Z","timestamp":1768192965114,"version":"3.49.0"},"reference-count":46,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"\n Background<\/jats:title>\n The HIV incidence among Chinese men who have sex with men (MSM) has still been high over the past decade. Despite HIV pre-exposure prophylaxis (PrEP) being an effective prevention strategy, few studies have examined PrEP uptake and adherence in China. This study examined PrEP initiation and adherence among Chinese MSM enrolled in a multi-site PrEP demonstration trial.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Three-month data for this study were drawn from a PrEP demonstration project in Guangzhou and Wuhan, China. The project aimed to increase the engagement of MSM in China for HIV\/STI screening, HIV risk reduction, and PrEP initiation and adherence through the use of a mobile phone app and community engagement with crowdsourcing of messages and study images. Part of the intervention was the provision of tenofovir\/emtricitabine as PrEP through two types of modalities: (1) once-daily oral dose (Daily-PrEP), or (2) event-driven dose (i.e. the 2\u00a0+\u00a01\u00a0+\u00a01 approach, Event-Driven PrEP). The outcome of interest was PrEP adherence, defined as missing fewer than five pills in the past 30\u00a0days for Daily PrEP, and no missed doses for the Event-Driven PrEP regimen. Univariate and multivariate logistic regressions were conducted for data analyses.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 927 individuals started PrEP, with follow-up data available for 650 people (70%) after 3\u00a0months. There were 593 men with a median age of 30 years (range\u00a021\u201361 years) in this study. Of those people, 341 reported taking Daily-PrEP, and 93% (317\/341) reported missing fewer than five pills in the past 30\u00a0days. Among 252 participants who reported taking the Event-Driven PrEP regimen, 61.5% (155\/252) reported full adherence. Daily-PrEP users were more likely to report good adherence than Event-Driven PrEP users (OR\u00a07.28, P\u00a0&lt;\u00a00.0001, 95% CI: 4.28\u201312.39).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n We observed a higher adherence to daily PrEP compared with Event-Driven PrEP among a sample of MSM in China. Further research is needed to examine long-term PrEP adherence among MSM in China.<\/jats:p>\n <\/jats:sec>","DOI":"10.1071\/sh25074","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:26:18Z","timestamp":1764746778000},"source":"Crossref","is-referenced-by-count":0,"title":["Daily PrEP and event-driven PrEP adherence for men who have sex with men in China"],"prefix":"10.1071","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-8919","authenticated-orcid":true,"given":"Fei","family":"Teng","sequence":"first","affiliation":[{"name":"ADepartment of Population Health Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. Email: fionafayeteng@gmail.com, pauburns@gmail.com, michael.welsch21@gmail.com, bwalker5@umc.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Burns","sequence":"additional","affiliation":[{"name":"ADepartment of Population Health Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. Email: fionafayeteng@gmail.com, pauburns@gmail.com, michael.welsch21@gmail.com, bwalker5@umc.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Welsch","sequence":"additional","affiliation":[{"name":"ADepartment of Population Health Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. Email: fionafayeteng@gmail.com, pauburns@gmail.com, michael.welsch21@gmail.com, bwalker5@umc.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Walker","sequence":"additional","affiliation":[{"name":"ADepartment of Population Health Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. Email: fionafayeteng@gmail.com, pauburns@gmail.com, michael.welsch21@gmail.com, bwalker5@umc.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Liang","sequence":"additional","affiliation":[{"name":"BZhongnan Hospital of Wuhan University, Wuhan, China. Email: keliang@whu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojie","family":"Huang","sequence":"additional","affiliation":[{"name":"CWuhan Tongxing LGBT Center, Wuhan, China. Email: huanghaojie1992@hotmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7012-5986","authenticated-orcid":true,"given":"Zhuoheng","family":"Yin","sequence":"additional","affiliation":[{"name":"DUniversity of North Carolina Project-China, Guangzhou, China. Email: zhuoheng.yin@seshglobal.org"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linghua","family":"Li","sequence":"additional","affiliation":[{"name":"EGuangzhou Eighth People\u2019s Hospital, Guangzhou, China. Email: llheliza@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9388-1799","authenticated-orcid":true,"given":"Chunyan","family":"Li","sequence":"additional","affiliation":[{"name":"FTokyo College, The University of Tokyo, Tokyo, Japan. Email: li.chunyan@mail.u-tokyo.ac.jp"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renslow","family":"Sherer","sequence":"additional","affiliation":[{"name":"GSection of Infectious Diseases and Global Health, Department of Medicine, The University of Chicago Medicine, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA. Email: rsherer@bsd.uchicago.edu, ahazra2@bsd.uchicago.edu, jlio@uchicago.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniruddha","family":"Hazra","sequence":"additional","affiliation":[{"name":"GSection of Infectious Diseases and Global Health, Department of Medicine, The University of Chicago Medicine, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA. Email: rsherer@bsd.uchicago.edu, ahazra2@bsd.uchicago.edu, jlio@uchicago.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Lio","sequence":"additional","affiliation":[{"name":"GSection of Infectious Diseases and Global Health, Department of Medicine, The University of Chicago Medicine, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA. Email: rsherer@bsd.uchicago.edu, ahazra2@bsd.uchicago.edu, jlio@uchicago.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danwen","family":"Qiu","sequence":"additional","affiliation":[{"name":"HGilead Sciences, Shanghai, China. Email: danwen.qiu@gilead.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-1181","authenticated-orcid":true,"given":"Joseph D.","family":"Tucker","sequence":"additional","affiliation":[{"name":"IInstitute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Email: jdtucker@med.unc.edu"},{"name":"JDermatology Hospital of Southern Medical University, Guangzhou, China."},{"name":"KClinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-707X","authenticated-orcid":true,"given":"Weiming","family":"Tang","sequence":"additional","affiliation":[{"name":"IInstitute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 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