{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T01:22:19Z","timestamp":1770859339107,"version":"3.50.1"},"reference-count":6,"publisher":"CSIRO Publishing","issue":"2","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A sustained outbreak of infectious syphilis has been documented in Australia since 2011. Although treatment of syphilis with antibiotics is highly effective, the ongoing spread of this pathogen in Australia suggests that diagnosis may be suboptimal. Molecular detection of syphilis is now commonly performed; however, in many instances clinicians request separate tests for specific pathogens, which may lead to issues in failing to request testing for Treponema pallidum subspecies pallidum, the causative agent of syphilis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we performed routine screening of 5052 samples submitted to our local pathology provider for routine herpes simplex virus investigations. Samples were tested for the presence of T. pallidum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified a total of 41 samples (0.8%) which were T. pallidum positive. Of these, the majority of samples reassuringly had requests for T. pallidum testing requested; however, samples from three patients (including a pregnant female) were identified as part of this exercise, who would have otherwise remained undetected and untreated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates the clear value in routine screening exercises such as this to improve the timely detection and management of syphilis in Australia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh25148","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T19:27:02Z","timestamp":1768332422000},"source":"Crossref","is-referenced-by-count":0,"title":["Is there value in routine screening exercises for syphilis? Coincidental syphilis detection in samples submitted for routine HSV investigations"],"prefix":"10.1071","volume":"23","author":[{"given":"Taylah K.","family":"Anderson","sequence":"first","affiliation":[{"name":"AThe University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Qld, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn W.","family":"Hume","sequence":"additional","affiliation":[{"name":"AThe University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Qld, Australia."},{"name":"BPathology Queensland Central Laboratory, Brisbane, Qld, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Gupta","sequence":"additional","affiliation":[{"name":"BPathology Queensland Central Laboratory, Brisbane, Qld, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-8661","authenticated-orcid":true,"given":"Michael","family":"Thomas","sequence":"additional","affiliation":[{"name":"BPathology Queensland Central Laboratory, Brisbane, Qld, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Whiley","sequence":"additional","affiliation":[{"name":"AThe University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Qld, Australia."},{"name":"BPathology Queensland Central Laboratory, Brisbane, Qld, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-6432","authenticated-orcid":true,"given":"Emma L.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"AThe University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Qld, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"2026021119564065700_R1","unstructured":"Australian Government Department of Health. National syphilis surveillance quarterly report \u2013 October to December 2024. Australian Government Department of Health; 2025."},{"issue":"1","key":"2026021119564065700_R2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0197-0070(85)80104-2","article-title":"Painless primary herpes.","volume":"6","author":"Silber","year":"1985","journal-title":"J Adolesc Health Care"},{"issue":"2","key":"2026021119564065700_R3","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1136\/sextrans-2015-052219","article-title":"Painful and multiple anogenital lesions are common in men with Treponema pallidum PCR-positive primary syphilis without herpes simplex virus coinfection: a cross-sectional clinic-based study.","volume":"92","author":"Towns","year":"2016","journal-title":"Sex Transm Infect"},{"issue":"12","key":"2026021119564065700_R4","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1080\/14787210.2023.2280214","article-title":"Advantages and limitations of current diagnostic laboratory approaches in syphilis and congenital syphilis.","volume":"21","author":"Cao","year":"2023","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"6","key":"2026021119564065700_R5","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1071\/SH15043","article-title":"Treatment and outcomes of polymerase chain reaction-confirmed early syphilis.","volume":"12","author":"Read","year":"2015","journal-title":"Sex Health"},{"issue":"6","key":"2026021119564065700_R6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1136\/sti.79.6.479","article-title":"Use of PCR in the diagnosis of early syphilis in the United Kingdom.","volume":"79","author":"Palmer","year":"2003","journal-title":"Sex Transm Infect"}],"container-title":["Sexual Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/doi\/10.1071\/SH25148\/1856301\/sh25148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/sh\/article-pdf\/doi\/10.1071\/SH25148\/1856301\/sh25148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:56:49Z","timestamp":1770857809000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/sh\/article\/23\/2\/SH25148\/268283\/Is-there-value-in-routine-screening-exercises-for"}},"subtitle":[],"editor":[{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4,9]]}},"URL":"https:\/\/doi.org\/10.1071\/sh25148","relation":{},"ISSN":["1448-5028","1449-8987"],"issn-type":[{"value":"1448-5028","type":"print"},{"value":"1449-8987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"article-number":"SH25148"}}