{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:47:24Z","timestamp":1782960444983,"version":"3.54.5"},"reference-count":33,"publisher":"CSIRO Publishing","issue":"4","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,17]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-occupational post-exposure prophylaxis (nPEP) has been proposed as a strategic entry point for identifying candidates for HIV pre-exposure prophylaxis (PrEP). However, evidence of its ability to engage at-risk populations beyond gay and bisexual men who have sex with men remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, real-world analysis of all individuals who accessed nPEP at a tertiary care centre in Italy between 2018 and 2025. Demographic and behavioural characteristics were evaluated to identify factors associated with PrEP initiation after nPEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 585 enrolled individuals, 149 (25.5%) initiated PrEP. PrEP uptake was strongly associated with being a gay or bisexual man who has sex with men and with repeated nPEP courses. In contrast, women, individuals aged &amp;lt;25\u00a0years, sex workers, transgender women, ethnic minorities and people using recreational drugs showed no increased likelihood of initiating PrEP. The introduction of free-of-charge PrEP did not improve engagement in these groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real-world setting, nPEP failed to facilitate PrEP uptake among non-gay and bisexual men who have sex with men at risk of HIV infection. Alternative implementation strategies are needed to increase PrEP access for these diverse key populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/sh26022","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:27:07Z","timestamp":1782959227000},"source":"Crossref","is-referenced-by-count":0,"title":["Non-occupational post-exposure prophylaxis does not expand or differentiate candidates for pre-exposure prophylaxis"],"prefix":"10.1071","volume":"23","author":[{"given":"Nicholas Brian","family":"Bana","sequence":"first","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Francesco","family":"Rezzonico","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Cavazza","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."},{"name":"BSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Baiguera","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Jole","family":"Burastero","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Raimondi","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Di Gennaro","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."},{"name":"BSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Luzi","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."},{"name":"BSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Forni","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."},{"name":"BSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Peracchi","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."},{"name":"BSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Travi","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merli","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Puoti","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."},{"name":"BSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-8789","authenticated-orcid":true,"given":"Roberto","family":"Rossotti","sequence":"additional","affiliation":[{"name":"AASST Grande Ospedale Metropolitano Niguarda, Milan, Italy."},{"name":"CDepartment of Diagnostics and Public Health, University of Verona, Verona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"2026070122270077900_R1","unstructured":"UNAIDS. 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