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Significantly, the expression of familial Parkinson's disease-linked mutant \u03b1-Syn is associated with the enhanced cellular accumulation of \u03b1-Syn\u0394C. Moreover, substoichiometric amounts of \u03b1-Syn\u0394C enhance the<jats:italic>in vitro<\/jats:italic>aggregation of the more abundant full-length \u03b1-Syn. Finally, cases of \u03b1-synucleinopathy exhibit increases in the total soluble \u03b1-Syn and a higher proportion of soluble \u03b1-Syn\u0394C, a condition favoring the aggregation of \u03b1-Syn. Collectively, our results indicate that the biology behind the generation and accumulation of \u03b1-Syn\u0394C is likely to have relevance for the initiation and the progression of \u03b1-Syn aggregation<jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1073\/pnas.0406976102","type":"journal-article","created":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T01:24:43Z","timestamp":1107221083000},"page":"2162-2167","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":430,"title":["Aggregation promoting C-terminal truncation of \u03b1-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations"],"prefix":"10.1073","volume":"102","author":[{"given":"Wenxue","family":"Li","sequence":"first","affiliation":[{"name":"Departments of Pathology, Neurology, Neuroscience, and Psychiatry and Udall Parkinson's Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205; 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