{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:48:52Z","timestamp":1778885332805,"version":"3.51.4"},"reference-count":36,"publisher":"Proceedings of the National Academy of Sciences","issue":"47","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2004,11,23]]},"abstract":"<jats:p>\n            Sex pheromones released by female moths are detected with high specificity and sensitivity in the olfactory sensilla of antennae of conspecific males. Bombykol in the silkmoth\n            <jats:italic>Bombyx mori<\/jats:italic>\n            was the first sex pheromone to be identified. Here we identify a male-specific G protein-coupled olfactory receptor gene,\n            <jats:italic>B. mori<\/jats:italic>\n            olfactory receptor 1 (\n            <jats:italic>BmOR-1<\/jats:italic>\n            ), that appears to encode a bombykol receptor. The\n            <jats:italic>BmOR-1<\/jats:italic>\n            gene is located on the Z sex chromosome, has an eight-exon\/seven-intron structure, and exhibits male-specific expression in the pheromone receptor neurons of male moth antenna during late pupal and adult stages. Bombykol stimulation of\n            <jats:italic>Xenopus laevis<\/jats:italic>\n            oocytes expressing BmOR-1 and BmG\u03b1q elicited robust dose-dependent inward currents on two-electrode voltage clamp recordings, demonstrating that the binding of bombykol to BmOR-1 leads to the activation of a BmG\u03b1q-mediated signaling cascade. Antennae of female moths infected with\n            <jats:italic>BmOR-1<\/jats:italic>\n            -recombinant baculovirus showed electrophysiological responses to bombykol but not to bombykal. These results provide evidence that BmOR-1 is a G protein-coupled sex pheromone receptor that recognizes bombykol.\n          <\/jats:p>","DOI":"10.1073\/pnas.0407596101","type":"journal-article","created":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T01:25:25Z","timestamp":1100568325000},"page":"16653-16658","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":360,"title":["Identification and functional characterization of a sex pheromone receptor in the silkmoth\n            <i>Bombyx mori<\/i>"],"prefix":"10.1073","volume":"101","author":[{"given":"Takeshi","family":"Sakurai","sequence":"first","affiliation":[{"name":"Divisions of Applied Biosciences and Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan; Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; and National..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Divisions of Applied Biosciences and Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan; Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; and National..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidefumi","family":"Mitsuno","sequence":"additional","affiliation":[{"name":"Divisions of Applied Biosciences and Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan; Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; and National..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Mori","sequence":"additional","affiliation":[{"name":"Divisions of Applied Biosciences and Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan; Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; and National..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Endo","sequence":"additional","affiliation":[{"name":"Divisions of Applied Biosciences and Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan; Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; and National..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintarou","family":"Tanoue","sequence":"additional","affiliation":[{"name":"Divisions of Applied Biosciences and Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan; Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; and National..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Yasukochi","sequence":"additional","affiliation":[{"name":"Divisions of Applied Biosciences and Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan; Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; and National..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Touhara","sequence":"additional","affiliation":[{"name":"Divisions of Applied Biosciences and Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan; Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; and National..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Divisions of Applied Biosciences and Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan; Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; and National..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"341","published-online":{"date-parts":[[2004,11,15]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/183055a0"},{"key":"e_1_3_2_2_2","first-page":"283","volume":"14","year":"1959","unstructured":"Butenandt, V. 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