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Stimulation is observed on a variety of flap, nick, and gapped substrates simulating repair intermediates. Blocking 9-1-1 entry to the double strands prevents a portion of the stimulation. Like PCNA stimulation, 9-1-1 stimulation cannot circumvent the tracking mechanism by which FEN1 enters the substrate; however, 9-1-1 does not substitute for PCNA in the stimulation of DNA polymerase \u03b2. This suggests that 9-1-1 is a damage-specific activator of FEN1.<\/jats:p>","DOI":"10.1073\/pnas.0407686101","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T20:14:13Z","timestamp":1100895253000},"page":"16762-16767","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":79,"title":["The human Rad9\u2013Rad1\u2013Hus1 checkpoint complex stimulates flap endonuclease 1"],"prefix":"10.1073","volume":"101","author":[{"given":"Wensheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235-1634; and Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; 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