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In addition, MHC-Angptl4 mice also exhibit hypertriglyceridemia after 6 h of fasting. We use echocardiography to show that MHC-Angptl4 mice develop left-ventricular dysfunction. Comparison of the metabolic profiles of isolated working hearts demonstrates that cardiac impairment in MHC-Angptl4 mice is positively associated with decreased triglyceride (TG) utilization. When bred to transgenic mice that overexpress acyl-CoA synthetase in the heart, a strain that exhibits elevated cardiac TG accumulation, cardiac TG content in double transgenic mice is reversed to that of wild-type mice. Taken together, our data support the hypothesis that induction of Angptl4 in the heart inhibits lipoprotein-derived fatty acid delivery. This mouse model will be useful to elucidate the role of reduced fatty acid supply in the pathogenesis of heart failure and related disorders.<\/jats:p>","DOI":"10.1073\/pnas.0409564102","type":"journal-article","created":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T01:24:45Z","timestamp":1106184285000},"page":"1767-1772","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":92,"title":["Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart"],"prefix":"10.1073","volume":"102","author":[{"given":"Xinxin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Physiology, Touchstone Center for Diabetes Research, Department of Radiology, Mary Nell and Ralph B. Rogers NMR Center, and Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390; and Department of Metabolic Disorders, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065"}]},{"given":"Shawn C.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Physiology, Touchstone Center for Diabetes Research, Department of Radiology, Mary Nell and Ralph B. Rogers NMR Center, and Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390; and Department of Metabolic Disorders, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065"}]},{"given":"Hongfei","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Physiology, Touchstone Center for Diabetes Research, Department of Radiology, Mary Nell and Ralph B. 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