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Consistent with this global role in transcription, MLL1 also localizes to microRNA (miRNA) loci that are involved in leukemia and hematopoiesis. In contrast to the 5\u2032 proximal binding behavior at most protein-coding genes, MLL1 occupies an extensive domain within a transcriptionally active region of the HoxA cluster. The ability of MLL1 to serve as a start site-specific global transcriptional regulator and to participate in larger chromatin domains at the Hox genes reveals dual roles for MLL1 in maintenance of cellular identity.<\/jats:p>","DOI":"10.1073\/pnas.0503072102","type":"journal-article","created":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T03:04:15Z","timestamp":1118199855000},"page":"8603-8608","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":300,"title":["Global and Hox-specific roles for the MLL1 methyltransferase"],"prefix":"10.1073","volume":"102","author":[{"given":"Matthew G.","family":"Guenther","sequence":"first","affiliation":[{"name":"Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142; Institute of Genetics, Ohio State University, Columbus, OH 43210; Weizmann Institute of Science, Rehovot 76100, Israel; and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 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