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Here, we demonstrate that the histone deacetylase inhibitor, trichostatin A, significantly down-regulated<jats:italic>CD154<\/jats:italic>and<jats:italic>IL-10<\/jats:italic>and up-regulated<jats:italic>IFN-<\/jats:italic>\u03b3 gene expression in SLE T cells. This reversal corrected the aberrant expression of these gene products, thereby enhancing IFN-\u03b3 production and inhibiting IL-10 and CD154 expression. That trichostatin A can simultaneously reverse the skewed expression of multiple genes implicated in the immunopathogenesis of SLE suggests that this pharmacologic agent may be a candidate for the treatment of this autoimmune disease.<\/jats:p>","DOI":"10.1073\/pnas.051507098","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:36:44Z","timestamp":1027694204000},"page":"2628-2633","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":151,"title":["Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-\u03b3 gene and protein expression in lupus T cells"],"prefix":"10.1073","volume":"98","author":[{"given":"Nilamadhab","family":"Mishra","sequence":"first","affiliation":[{"name":"Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157"}]},{"given":"Doris 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