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StarD4, StarD5, and StarD6 are 205- to 233-aa proteins consisting almost entirely of START domains. These three constitute a subfamily among START proteins, sharing \u224830% amino acid identity with one another, \u224820% identity with the cholesterol-binding START domains of StAR and MLN64, and less than 15% identity with phosphatidylcholine transfer protein (PCTP) and other START domains. StarD4 and StarD5 were expressed in most tissues, with highest levels in liver and kidney, whereas StarD6 was expressed exclusively in the testis. In contrast to StarD4, expression of StarD5 and MLN64 was not sterol-regulated. StarD4, StarD5, and StarD6 may be involved in the intracellular transport of sterols or other lipids.<\/jats:p>","DOI":"10.1073\/pnas.052143799","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:46:49Z","timestamp":1027694809000},"page":"6943-6948","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":167,"title":["The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6"],"prefix":"10.1073","volume":"99","author":[{"given":"Raymond E.","family":"Soccio","sequence":"first","affiliation":[{"name":"Laboratory of Biochemical Genetics and Metabolism, Laboratories of Molecular Biophysics, and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel 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