{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T11:17:12Z","timestamp":1774783032733,"version":"3.50.1"},"reference-count":23,"publisher":"Proceedings of the National Academy of Sciences","issue":"5","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,3,5]]},"abstract":"<jats:p>Human chromosomes 21 and 22 (mainly the q-arms) were the first complete parts of the human genome released. Our analysis of genes, pseudogenes (\u03a8g), and Alu repeats across these chromosomes include the following findings: The number of gene structures containing untranslated exons exceeds 25%; the terminal exon tends to be the largest among exons, whereas, the initial intron tends to be the largest among introns; single-exon gene length is approximately the mean gene exon number times the mean internal exon length; processed \u03a8g lengths are on average approximately the same as single-exon gene length; and the G+C content and length of genes are uncorrelated. The counts and distribution of genes, \u03a8g, and Alu sequences and G+C variation are evaluated with respect to clusters and overdispersions. Other assessments concern comparisons of intergenic lengths, properties of \u03a8g sequences, and correlations between Alu and \u03a8g sequences.<\/jats:p>","DOI":"10.1073\/pnas.052692099","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:37:36Z","timestamp":1027694256000},"page":"2930-2935","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":54,"title":["Genes, pseudogenes, and Alu sequence organization across human chromosomes 21 and 22"],"prefix":"10.1073","volume":"99","author":[{"given":"Chingfer","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Mathematics, Stanford University, Stanford, CA 94305-2125; and Genetic Information Research Institute, 2081 Landings Drive, Mountain View, CA 94043"}]},{"given":"Andrew J.","family":"Gentles","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Stanford University, Stanford, CA 94305-2125; and Genetic Information Research Institute, 2081 Landings Drive, Mountain View, CA 94043"}]},{"given":"Jerzy","family":"Jurka","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Stanford University, Stanford, CA 94305-2125; and Genetic Information Research Institute, 2081 Landings Drive, Mountain View, CA 94043"}]},{"given":"Samuel","family":"Karlin","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Stanford University, Stanford, CA 94305-2125; and Genetic Information Research Institute, 2081 Landings Drive, Mountain View, CA 94043"}]}],"member":"341","published-online":{"date-parts":[[2002,2,26]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/35057062"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058040"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/990031"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35012518"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6640"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00185-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.163101"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00135-3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.7.3788"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.10.3462-3471.2001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.32.1.279"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(98)01648-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6363"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08867.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(98)80067-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00163235"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.19.120185.001345"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.207102"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-437X(95)80044-1"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02515383"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00163207"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1621093"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.5.919"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.052692099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T18:47:03Z","timestamp":1649789223000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.052692099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,26]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,3,5]]}},"alternative-id":["10.1073\/pnas.052692099"],"URL":"https:\/\/doi.org\/10.1073\/pnas.052692099","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2,26]]},"assertion":[{"value":"2001-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}