{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:18:21Z","timestamp":1770063501616,"version":"3.49.0"},"reference-count":39,"publisher":"Proceedings of the National Academy of Sciences","issue":"15","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,4,11]]},"abstract":"<jats:p>\n            PINC is a large, alternatively spliced, developmentally regulated, noncoding RNA expressed in the regressed terminal ductal lobular unit-like structures of the parous mammary gland. Previous studies have shown that this population of cells possesses not only progenitor-like qualities (the ability to proliferate and repopulate a mammary gland) and the ability to survive developmentally programmed cell death but also the inhibition of carcinogen-induced proliferation. Here we report that PINC expression is temporally and spatially regulated in response to developmental stimuli\n            <jats:italic>in vivo<\/jats:italic>\n            and that PINC RNA is localized to distinct foci in either the nucleus or the cytoplasm in a cell-cycle-specific manner. Loss-of-function experiments suggest that PINC performs dual roles in cell survival and regulation of cell-cycle progression, suggesting that PINC may contribute to the developmentally mediated changes previously observed in the terminal ductal lobular unit-like structures of the parous gland. This is one of the first reports describing the functional properties of a large, developmentally regulated, mammalian, noncoding RNA.\n          <\/jats:p>","DOI":"10.1073\/pnas.0600745103","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T01:40:47Z","timestamp":1143769247000},"page":"5781-5786","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":146,"title":["A noncoding RNA is a potential marker of cell fate during mammary gland development"],"prefix":"10.1073","volume":"103","author":[{"given":"Melanie R.","family":"Ginger","sequence":"first","affiliation":[{"name":"Departments of *Molecular and Cellular Biology and"}]},{"given":"Amy N.","family":"Shore","sequence":"additional","affiliation":[{"name":"Program in Developmental Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030; and"}]},{"given":"Alejandro","family":"Contreras","sequence":"additional","affiliation":[{"name":"Departments of *Molecular and Cellular Biology and"}]},{"given":"Monique","family":"Rijnkels","sequence":"additional","affiliation":[{"name":"U.S. Department of Agriculture\/Agricultural Research Services Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030"}]},{"given":"Jonathan","family":"Miller","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology and"}]},{"given":"Maria F.","family":"Gonzalez-Rimbau","sequence":"additional","affiliation":[{"name":"Departments of *Molecular and Cellular Biology and"}]},{"given":"Jeffrey M.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Departments of *Molecular and Cellular Biology and"}]}],"member":"341","published-online":{"date-parts":[[2006,4,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10332"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01266"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2094104"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2722704"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01262"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116800"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117806"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115901"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1011603"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.982903"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1055303"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20084"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/431757a"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1075103"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00127-8"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kve230"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend.15.11.0724"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.6.1377"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221459098"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr603"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb02725.x"},{"key":"e_1_3_3_22_2","first-page":"1765","volume":"59","author":"Chodosh L. 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