{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:03:23Z","timestamp":1778184203701,"version":"3.51.4"},"reference-count":36,"publisher":"Proceedings of the National Academy of Sciences","issue":"29","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,7,18]]},"abstract":"<jats:p>\n            Apoptosis of activated T cells is critical for the termination of immune responses. Here we show that adjuvant-stimulated dendritic cells secrete cytokines that prime activated T cells for survival and analyze the roles of the NF-\u03baB regulator Bcl-3 and the proapoptotic Bcl-2 family members Bim and Puma. Bcl-3 overexpression increased survival, and activated\n            <jats:italic>bcl-3<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            T cells died abnormally rapidly. Cytokines from adjuvant-stimulated dendritic cells induced Bcl-3, but survival through cytokine priming was Bcl-3-independent. Apoptosis inhibition by Bcl-3 involved blockade of Bim activation, because Bim was overactivated in Bcl-3-deficient cells, and Bcl-3 failed to increase survival of\n            <jats:italic>bim<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            T cells. However, adjuvants increased survival also in Bim-deficient T cells. This Bim-independent death pathway is at least in part regulated by Puma, as shown by analysis of puma\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            and noxa\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            T cells. IL-1, IL-7, and IL-15 primed T cells for survival even in the absence of Bim or Puma. Our data define interrelations and a Bim-independent pathway to activated T cell death.\n          <\/jats:p>","DOI":"10.1073\/pnas.0603625103","type":"journal-article","created":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:34:20Z","timestamp":1152578060000},"page":"10979-10984","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":79,"title":["The NF-\u03baB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells"],"prefix":"10.1073","volume":"103","author":[{"given":"Anette","family":"Bauer","sequence":"first","affiliation":[{"name":"*Institute for Medical Microbiology, Technical University Munich, Trogerstrasse 9, D-81675 Munich, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Villunger","sequence":"additional","affiliation":[{"name":"Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Labi","sequence":"additional","affiliation":[{"name":"Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke F.","family":"Fischer","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3050, Australia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Strasser","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3050, Australia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Wagner","sequence":"additional","affiliation":[{"name":"*Institute for Medical Microbiology, Technical University Munich, Trogerstrasse 9, D-81675 Munich, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland M.","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Technical University Munich, Ismaningerstrasse 22, D-81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"H\u00e4cker","sequence":"additional","affiliation":[{"name":"*Institute for Medical Microbiology, Technical University Munich, Trogerstrasse 9, D-81675 Munich, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"341","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1568"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104554"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2336198100"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00322-9"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1126903"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400998"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099320"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5445.1735"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90362-3"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/87692"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90980-X"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90050-0"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2542004pe48"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80456-6"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090072"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00214-3"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00213-1"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.201208798"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00244-7"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3810"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.3.521"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.5024"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00728-4"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00239-2"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00238-0"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg635"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062257"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402293101"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3620"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401471101"},{"key":"e_1_3_4_31_2","author":"You H.","year":"2006","unstructured":"H. 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