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In contrast, p38 MAP kinase inhibition alone fails to rescue heart function despite increased cardiomyocyte mitosis. FGF1 improves angiogenesis, possibly contributing to the survival of newly generated cardiomyocytes. Our data indicate that FGF1 and p38 MAP kinase, proteins involved in cardiomyocyte proliferation and angiogenesis during development, may be delivered therapeutically to enhance cardiac regeneration.<\/jats:p>","DOI":"10.1073\/pnas.0607382103","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T22:54:28Z","timestamp":1160520868000},"page":"15546-15551","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":329,"title":["FGF1\/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction"],"prefix":"10.1073","volume":"103","author":[{"given":"Felix B.","family":"Engel","sequence":"first","affiliation":[{"name":"*Department of Pediatrics, Harvard Medical School, and Department of Cardiology, Children's Hospital, 320 Longwood Avenue, Boston, MA 02115;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick C. 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