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Examining the role of intrinsic mitochondrial caspase-dependent apoptosis and caspase-independent, reactive oxygen species (ROS) facilitated cell death, has provided an understanding of mechanisms that may determine the varied response to the histone deacetylase inhibitor. We found striking differences among these cancer cells in constitutive expression and response to suberoylanilide hydroxamic acid in levels of antiapoptotic and proapoptotic proteins, mitochondria membrane integrity, activation of caspases, ROS accumulation, and expression of thioredoxin, the major scavenger of ROS. Identifying these differences can have predictive value in assessing therapeutic response and identifying targets to enhance therapeutic efficacy.<\/jats:p>","DOI":"10.1073\/pnas.0607518103","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T01:02:33Z","timestamp":1160442153000},"page":"15540-15545","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":148,"title":["Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitor"],"prefix":"10.1073","volume":"103","author":[{"given":"Weisheng","family":"Xu","sequence":"first","affiliation":[{"name":"Memorial Sloan\u2013Kettering Cancer Center, 1275 York Avenue, New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Ngo","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2013Kettering Cancer Center, 1275 York Avenue, New York, NY 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