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Like Brefeldin A (BFA), Exo1 induces the rapid release of ADP-ribosylation  factor (ARF) 1 from Golgi membranes but has less effect on the organization of  the trans-Golgi network. Our data indicate that Exo1 acts by a different  mechanism from BFA. Unlike BFA, Exo1 does not induce the ADP-ribosylation of  CtBP\/Bars50 and does not interfere with the activity of guanine nucleotide  exchange factors specific for Golgi-based ARFs. Thus, Exo1 allows the fatty  acid exchange activity of Bars50 to be distinguished from ARF1 activity in the  control of Golgi tubulation.<\/jats:p>","DOI":"10.1073\/pnas.0631766100","type":"journal-article","created":{"date-parts":[[2003,5,27]],"date-time":"2003-05-27T13:10:32Z","timestamp":1054041032000},"page":"6469-6474","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":145,"title":["Exo1: A new chemical inhibitor of the exocytic pathway"],"prefix":"10.1073","volume":"100","author":[{"given":"Yan","family":"Feng","sequence":"first","affiliation":[{"name":"Institute of Chemistry and Cell Biology, Department of Cell Biology, and Center for Blood Research, Harvard Medical School, Boston, MA 02115; Department of Biochemistry, University of Texas Southwestern Medical Center,  Dallas, TX 75235; Department of Cell Biology, University of Alberta, Edmonton, AB, Canada T6G  2H7; and Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la  Recherche Scientifique\u2013Unit\u00e9 Mixte de Recherche 6097, 06560  Valbonne Sophia-Antipolis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Cell Biology, Department of Cell Biology, and Center for Blood Research, Harvard Medical School, Boston, MA 02115; Department of Biochemistry, University of Texas Southwestern Medical Center,  Dallas, TX 75235; Department of Cell Biology, University of Alberta, Edmonton, AB, Canada T6G  2H7; and Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la  Recherche Scientifique\u2013Unit\u00e9 Mixte de Recherche 6097, 06560  Valbonne Sophia-Antipolis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy K. 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