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This proapoptotic activity of TrkC relies on the caspase-mediated cleavage of the intracellular domain of TrkC, which permits the release of a proapoptotic fragment. This fragment induces apoptosis through a caspase-9-dependent mechanism. Finally, we show that the death of dorsal root ganglion (DRG) neurons provoked by NT-3 withdrawal is inhibited when TrkC-proapoptotic activity is antagonized. Thus, the death of neurons upon disappearance of NT-3 is not only due to a loss of survival signals but also to the active proapoptotic activity of the unbound TrkC dependence receptor.<\/jats:p>","DOI":"10.1073\/pnas.0701243104","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T01:10:08Z","timestamp":1186621808000},"page":"13361-13366","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":86,"title":["The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm"],"prefix":"10.1073","volume":"104","author":[{"given":"Servane","family":"Tauszig-Delamasure","sequence":"first","affiliation":[{"name":"*Apoptosis, Cancer and Development Laboratory, Equipe Labellis\u00e9e La Ligue, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5238, Universit\u00e9 de Lyon, Centre L\u00e9on B\u00e9rard, 69008 Lyon, France; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ying","family":"Yu","sequence":"additional","affiliation":[{"name":"Research Program in Molecular Neurobiology, University of Helsinki, P.O. 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