{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:09:24Z","timestamp":1773904164575,"version":"3.50.1"},"reference-count":38,"publisher":"Proceedings of the National Academy of Sciences","issue":"15","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,4,13]]},"abstract":"<jats:p>\n            Multiple intracellular signals are altered in Alzheimer's disease brain tissues, including the PI3K\/Akt pathway. However, the pathological relevance of such alterations is poorly understood. In vitro studies yield results that seem to be consistent with the conventional perception in which an up-regulation of the cell survival pathway, PI3K pathway, is protective in Alzheimer's disease pathogenesis. The current in vivo genetic approach, however, reveals that inhibition of the PI3K pathway leads to rescuing of the \u03b2-amyloid peptide (A\u03b2)-induced memory loss in the\n            <jats:italic>Drosophila<\/jats:italic>\n            brain. We began our inquiry into the molecular basis of this memory loss by studying A\u03b242-induced enhancement of long-term depression. We found that long-term depression is restored to a normal level through inhibition of PI3K activity. A\u03b242-induced PI3K hyperactivity is directly confirmed by immunostaining of the PI3K phosphorylation targets, phospholipids. Such observations lead to the following demonstration that A\u03b242-induced memory loss can be rescued through genetic silencing or pharmacological inhibition of PI3K functions. Our data suggest that A\u03b242 stimulates PI3K, which in turn causes memory loss in association with an increase in accumulation of A\u03b242 aggregates.\n          <\/jats:p>","DOI":"10.1073\/pnas.0909314107","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T03:49:26Z","timestamp":1269920966000},"page":"7060-7065","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":121,"title":["PI3 kinase signaling is involved in A\u03b2-induced memory loss in\n            <i>Drosophila<\/i>"],"prefix":"10.1073","volume":"107","author":[{"given":"Hsueh-Cheng","family":"Chiang","sequence":"first","affiliation":[{"name":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;"},{"name":"Department of Neuroscience, State University of New York, Stony Brook, NY 11794;"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Biotechnology, Tsinghua 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