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Severe muscle injury (rhabdomyolysis) is accompanied by the release of myoglobin that becomes deposited in the kidney, causing renal injury. We previously showed in a rat model of rhabdomyolysis that redox cycling between ferric and ferryl myoglobin yields radical species that cause severe oxidative damage to the kidney. In this model, acetaminophen at therapeutic plasma concentrations significantly decreased oxidant injury in the kidney, improved renal function, and reduced renal damage. These findings also provide a hypothesis for potential therapeutic applications for acetaminophen in diseases involving hemoprotein-mediated oxidative injury.<\/jats:p>","DOI":"10.1073\/pnas.0910174107","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T03:51:30Z","timestamp":1265082690000},"page":"2699-2704","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":142,"title":["Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure"],"prefix":"10.1073","volume":"107","author":[{"given":"Olivier","family":"Boutaud","sequence":"first","affiliation":[{"name":"Departments of aPharmacology,"}]},{"given":"Kevin P.","family":"Moore","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, University College London Medical School, London NW3 2QG, United Kingdom"}]},{"given":"Brandon J.","family":"Reeder","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, United Kingdom; and"}]},{"given":"David","family":"Harry","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, University College London Medical School, London NW3 2QG, United Kingdom"}]},{"given":"Alexander J.","family":"Howie","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, University College London Medical School, London NW3 2QG, United Kingdom"}]},{"given":"Shuhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"}]},{"given":"Clare K.","family":"Carney","sequence":"additional","affiliation":[{"name":"Chemistry, Vanderbilt University, Nashville, TN 37232;"}]},{"given":"Tina S.","family":"Masterson","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"}]},{"given":"Taneem","family":"Amin","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"}]},{"given":"David W.","family":"Wright","sequence":"additional","affiliation":[{"name":"Chemistry, Vanderbilt University, Nashville, TN 37232;"}]},{"given":"Michael T.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, United Kingdom; and"}]},{"given":"John A.","family":"Oates","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"},{"name":"Medicine, and"}]},{"suffix":"II","given":"L. 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