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Combination of activated PI3K signaling and heightened androgen receptor signaling, which is associated with disease progression to androgen independence, was also performed. Even though luminal cells fail to respond, basal\/stem cells demonstrate efficient capacity for cancer initiation and can produce luminal-like disease characteristic of human prostate cancer in multiple models. This finding provides evidence in support of basal epithelial stem cells as one target cell for prostate cancer initiation and demonstrates the propensity of primitive cells for tumorigenesis.<\/jats:p>","DOI":"10.1073\/pnas.0913873107","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T02:54:47Z","timestamp":1264474487000},"page":"2610-2615","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":231,"title":["Basal epithelial stem cells are efficient targets for prostate cancer initiation"],"prefix":"10.1073","volume":"107","author":[{"given":"Devon A.","family":"Lawson","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and"}]},{"given":"Yang","family":"Zong","sequence":"additional","affiliation":[{"name":"The Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095;"}]},{"given":"Sanaz","family":"Memarzadeh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology,"}]},{"given":"Li","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"}]},{"given":"Jiaoti","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, and"}]},{"given":"Owen N.","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and"},{"name":"The Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095;"},{"name":"Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; and"}]}],"member":"341","published-online":{"date-parts":[[2010,1,25]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"122","article-title":"Carcinoma of the prostate: overview of the most common malignancy in men","volume":"67","author":"Carson CC","year":"2006","unstructured":"CC Carson, Carcinoma of the prostate: overview of the most common malignancy in men. 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