{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T08:30:29Z","timestamp":1775809829294,"version":"3.50.1"},"reference-count":52,"publisher":"Proceedings of the National Academy of Sciences","issue":"12","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,6,6]]},"abstract":"<jats:p>\n            Huntington's Disease (HD) is caused by an expansion of a polyglutamine tract within the huntingtin (htt) protein. Pathogenesis in HD appears to include the cytoplasmic cleavage of htt and release of an amino-terminal fragment capable of nuclear localization. We have investigated potential consequences to nuclear function of a pathogenic amino-terminal region of htt (httex1p) including aggregation, protein\u2013protein interactions, and transcription. httex1p was found to coaggregate with p53 in inclusions generated in cell culture and to interact with p53\n            <jats:italic>in vitro<\/jats:italic>\n            and in cell culture. Expanded httex1p represses transcription of the p53-regulated promoters,\n            <jats:italic>\n              p21\n              <jats:sup>WAF1\/CIP1<\/jats:sup>\n            <\/jats:italic>\n            and\n            <jats:italic>MDR-1<\/jats:italic>\n            . httex1p was also found to interact\n            <jats:italic>in vitro<\/jats:italic>\n            with CREB-binding protein (CBP) and mSin3a, and CBP to localize to neuronal intranuclear inclusions in a transgenic mouse model of HD. These results raise the possibility that expanded repeat htt causes aberrant transcriptional regulation through its interaction with cellular transcription factors which may result in neuronal dysfunction and cell death in HD.\n          <\/jats:p>","DOI":"10.1073\/pnas.100110097","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:41:48Z","timestamp":1027694508000},"page":"6763-6768","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":843,"title":["The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription"],"prefix":"10.1073","volume":"97","author":[{"given":"Joan S.","family":"Steffan","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]},{"given":"Aleksey","family":"Kazantsev","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]},{"given":"Olivera","family":"Spasic-Boskovic","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]},{"given":"Marilee","family":"Greenwald","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]},{"given":"Ya-Zhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]},{"given":"Heike","family":"Gohler","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]},{"given":"Erich E.","family":"Wanker","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]},{"given":"Gillian P.","family":"Bates","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]},{"given":"David E.","family":"Housman","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]},{"given":"Leslie M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, D240 Medical Sciences I, University of California, Irvine, CA 92697-1700; Department of Biology Center for Cancer Research, Massachusetts Institute of Technology, Building E17-543, Cambridge, MA 02139; Medical and Molecular Genetics, GKT School of Medicine, King's College, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom; and Max-Planck-Institut fur Molekulare Genetik, Ihnestra\u00dfe 73, Berlin D-14195, Germany"}]}],"member":"341","published-online":{"date-parts":[[2000,5,23]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"141","volume-title":"Huntington's Disease","author":"Harper P S","year":"1991","unstructured":", ed P S Harper (W. 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