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The ribose of A76 of the peptidyl-tRNA adopts the C2\u2032-endo conformation, and the 2\u2032 hydroxyl of A76 is within hydrogen-bond distance of the 2\u2032 hydroxyl of A2451. The structure suggests how a catalytic water can be coordinated in the peptidyl transferase center and, together with previous biochemical and computational data, suggests a model for how the ester bond between the peptidyl tRNA and the nascent peptide is hydrolyzed.<\/jats:p>","DOI":"10.1073\/pnas.1003995107","type":"journal-article","created":{"date-parts":[[2010,4,27]],"date-time":"2010-04-27T01:49:06Z","timestamp":1272332946000},"page":"8593-8598","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":97,"title":["Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release"],"prefix":"10.1073","volume":"107","author":[{"given":"Hong","family":"Jin","sequence":"first","affiliation":[{"name":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom"}]},{"given":"Ann C.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom"}]},{"given":"David","family":"Loakes","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom"}]},{"given":"V.","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom"}]}],"member":"341","published-online":{"date-parts":[[2010,4,26]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/nature08403","article-title":"What recent ribosome structures have revealed about the mechanism of translation","volume":"461","author":"Schmeing TM","year":"2009","unstructured":"TM Schmeing, V Ramakrishnan, What recent ribosome structures have revealed about the mechanism of translation. 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