{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T01:17:21Z","timestamp":1783214241500,"version":"3.54.6"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"11","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,5,22]]},"abstract":"<jats:p>\n                    Endometrial stromal tumors are divided into three types: benign\n stromal nodules, endometrial stromal sarcomas, and undifferentiated\n endometrial sarcomas. A variety of cytogenetic abnormalities involving\n chromosome 7 have been reported in endometrial stromal sarcomas,\n including a recurrent t(7;17)(p15;q21). We have identified two zinc\n finger genes, which we have termed\n                    <jats:italic>JAZF1<\/jats:italic>\n                    and\n                    <jats:italic>JJAZ1<\/jats:italic>\n                    , at the sites of the 7p15 and 17q21 breakpoints.\n Analyses of tumor RNA indicate that a\n                    <jats:italic>JAZF1<\/jats:italic>\n                    \/\n                    <jats:italic>JJAZ1<\/jats:italic>\n                    fusion is present in all\n types of endometrial stromal tumors; however, the fusion appears to be\n rarer among endometrial stromal sarcomas that would be considered\n high-grade according to certain classification schemes. These findings\n suggest that the less malignant endometrial stromal tumors may evolve\n toward more malignant types, but that some endometrial stromal sarcomas\n with relatively abundant mitotic activity may compose a biologically\n distinct group.\n                  <\/jats:p>","DOI":"10.1073\/pnas.101132598","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:37:36Z","timestamp":1027679856000},"page":"6348-6353","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":342,"title":["Frequent fusion of the\n                    <i>JAZF1<\/i>\n                    and\n                    <i>JJAZ1<\/i>\n                    genes in endometrial stromal tumors"],"prefix":"10.1073","volume":"98","author":[{"given":"Jason I.","family":"Koontz","sequence":"first","affiliation":[{"name":"Division of Molecular Oncology, Department of\r Pathology, Brigham and Women's Hospital and Harvard Medical School,\r Boston, MA 02115; and Center for Human Genetics,\r University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Lee","family":"Soreng","sequence":"additional","affiliation":[{"name":"Division of Molecular Oncology, Department of\r Pathology, Brigham and Women's Hospital and Harvard Medical School,\r Boston, MA 02115; and Center for Human Genetics,\r University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Nucci","sequence":"additional","affiliation":[{"name":"Division of Molecular Oncology, Department of\r Pathology, Brigham and Women's Hospital and Harvard Medical School,\r Boston, MA 02115; and Center for Human Genetics,\r University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank C.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Molecular Oncology, Department of\r Pathology, Brigham and Women's Hospital and Harvard Medical School,\r Boston, MA 02115; and Center for Human Genetics,\r University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Division of Molecular Oncology, Department of\r Pathology, Brigham and Women's Hospital and Harvard Medical School,\r Boston, MA 02115; and Center for Human Genetics,\r University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"van den Berghe","sequence":"additional","affiliation":[{"name":"Division of Molecular Oncology, Department of\r Pathology, Brigham and Women's Hospital and Harvard Medical School,\r Boston, MA 02115; and Center for Human Genetics,\r University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Dal","family":"Cin","sequence":"additional","affiliation":[{"name":"Division of Molecular Oncology, Department of\r Pathology, Brigham and Women's Hospital and Harvard Medical School,\r Boston, MA 02115; and Center for Human Genetics,\r University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Division of Molecular Oncology, Department of\r Pathology, Brigham and Women's Hospital and Harvard Medical School,\r Boston, MA 02115; and Center for Human Genetics,\r University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Sklar","sequence":"additional","affiliation":[{"name":"Division of Molecular Oncology, Department of\r Pathology, Brigham and Women's Hospital and Harvard Medical School,\r Boston, MA 02115; and Center for Human Genetics,\r University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,5,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/978-1-4757-3889-6_13","volume-title":"Blaustein's Pathology of the Female Genital Tract","author":"Zaloudek C","year":"1994","unstructured":"C Zaloudek, H J Norris Blaustein's Pathology of the Female Genital Tract, ed R J Kurman (Springer, New York), pp. 487\u2013528 (1994)."},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196606)19:6<755::AID-CNCR2820190604>3.0.CO;2-U"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1981.tb01761.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821115)50:10<2170::AID-CNCR2820501033>3.0.CO;2-K"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199005000-00002"},{"key":"e_1_3_3_6_2","first-page":"2203","volume-title":"Diagnostic Surgical Pathology","author":"Hendrickson M R","year":"1999","unstructured":"M R Hendrickson, T A Longacre, R L Kempson Diagnostic Surgical Pathology, ed S S Sternberg (Lippincott Williams & Wilkins, Philadelphia), pp. 2203\u20132305 (1999)."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202526"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0697-639"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.2.163"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90073-4"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90062-D"},{"key":"e_1_3_3_12_2","first-page":"84","volume":"29","author":"Pauwels P","year":"1996","unstructured":"P Pauwels, P Dal Cin, C N Van de Moosdijk, L Vrints, R Sciot, H van den Berghe Histopathology 29, 84\u201387 (1996).","journal-title":"Histopathology"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(96)00393-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(91)94014-4"},{"key":"e_1_3_3_15_2","first-page":"6205","volume":"59","author":"Morgan J A","year":"1999","unstructured":"J A Morgan, Y Yin, A D Borowsky, F Kuo, N Nourmand, J I Koontz, C Reynolds, L Soreng, C A Griffin, F Graeme-Cook, et al. 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