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The results produced high-definition genomic profiles of clonal populations from 40 pancreatic adenocarcinomas and a set of prostate adenocarcinomas, including serial biopsies from a patient who progressed to androgen-independent metastatic disease. The genomes of clonal populations were found to have patient-specific aberrations of clinical relevance. Furthermore, we identified genomic aberrations specific to therapeutically responsive and resistant clones arising during the evolution of androgen-independent metastatic prostate adenocarcinoma. We also distinguished divergent clonal populations within single biopsies and mapped aberrations in multiple aneuploid populations arising in primary and metastatic pancreatic adenocarcinoma. We propose that our high-definition analyses of the genomes of distinct clonal populations of cancer cells in patients in vivo can help guide diagnoses and tailor approaches to personalized treatment.<\/jats:p>","DOI":"10.1073\/pnas.1104009108","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T23:40:37Z","timestamp":1309909237000},"page":"12054-12059","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":96,"title":["Advancing a clinically relevant perspective of the clonal nature of cancer"],"prefix":"10.1073","volume":"108","author":[{"given":"Christian","family":"Ruiz","sequence":"first","affiliation":[{"name":"Clinical Translational Research Division, Translational Genomics Research Institute, Scottsdale, AZ 85259;"},{"name":"Institute for Pathology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland;"}]},{"given":"Elizabeth","family":"Lenkiewicz","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Division, Translational Genomics Research Institute, Scottsdale, AZ 85259;"}]},{"given":"Lisa","family":"Evers","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Division, Translational Genomics Research Institute, Scottsdale, AZ 85259;"}]},{"given":"Tara","family":"Holley","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Division, Translational Genomics Research Institute, Scottsdale, AZ 85259;"}]},{"given":"Alex","family":"Robeson","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Division, Translational Genomics Research Institute, Scottsdale, AZ 85259;"}]},{"given":"Jeffrey","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Genetic Basis of Human Disease, Translational Genomics Research Institute, Phoenix, AZ 85004;"}]},{"given":"Michael J.","family":"Demeure","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Division, Translational Genomics Research Institute, Scottsdale, AZ 85259;"},{"name":"Virginia G. Piper Cancer Center, Scottsdale Healthcare, Scottsdale, AZ 85258;"}]},{"given":"Michael A.","family":"Hollingsworth","sequence":"additional","affiliation":[{"name":"Eppley Institute for Research in Cancer and Allied Diseases, Nebraska Medical Center, Omaha, NE 68198;"}]},{"given":"Michael","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle, WA 98105;"}]},{"given":"Donna","family":"Prunkard","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle, WA 98105;"}]},{"given":"Peter S.","family":"Rabinovitch","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle, WA 98105;"}]},{"given":"Tobias","family":"Zellweger","sequence":"additional","affiliation":[{"name":"Division of Urology, St. Claraspital and University of Basel, 4058 Basel, Switzerland;"}]},{"given":"Spyro","family":"Mousses","sequence":"additional","affiliation":[{"name":"Genetic Basis of Human Disease, Translational Genomics Research Institute, Phoenix, AZ 85004;"}]},{"given":"Jeffrey M.","family":"Trent","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Division, Translational Genomics Research Institute, Scottsdale, AZ 85259;"},{"name":"Van Andel Research Institute, Grand Rapids, MI 49503; and"}]},{"given":"John D.","family":"Carpten","sequence":"additional","affiliation":[{"name":"Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004"}]},{"given":"Lukas","family":"Bubendorf","sequence":"additional","affiliation":[{"name":"Institute for Pathology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland;"}]},{"given":"Daniel","family":"Von Hoff","sequence":"additional","affiliation":[{"name":"Clinical Translational Research Division, Translational Genomics Research Institute, Scottsdale, AZ 85259;"},{"name":"Virginia G. 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