{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:26:07Z","timestamp":1785446767224,"version":"3.56.0"},"reference-count":21,"publisher":"National Academy of Sciences","issue":"30","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2011,7,26]]},"abstract":"<jats:p>\n                    Here we report a human intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the\n                    <jats:italic>ZC3H14<\/jats:italic>\n                    gene that encodes a conserved polyadenosine RNA binding protein. We identify\n                    <jats:italic>ZC3H14<\/jats:italic>\n                    mRNA transcripts in the human central nervous system, and we find that rodent ZC3H14 protein is expressed in hippocampal neurons and colocalizes with poly(A) RNA in neuronal cell bodies. A\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    model of this disease created by mutation of the gene encoding the ZC3H14 ortholog dNab2, which also binds polyadenosine RNA, reveals that dNab2 is essential for development and required in neurons for normal locomotion and flight. Biochemical and genetic data indicate that dNab2 restricts bulk poly(A) tail length in vivo, suggesting that this function may underlie its role in development and disease. These studies reveal a conserved requirement for\n                    <jats:italic>ZC3H14\/dNab2<\/jats:italic>\n                    in the metazoan nervous system and identify a poly(A) RNA binding protein associated with a human brain disorder.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1107103108","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T00:49:29Z","timestamp":1309999769000},"page":"12390-12395","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":89,"title":["Mutation of the conserved polyadenosine RNA binding protein, ZC3H14\/dNab2, impairs neural function in\n                    <i>Drosophila<\/i>\n                    and humans"],"prefix":"10.1073","volume":"108","author":[{"given":"ChangHui","family":"Pak","sequence":"first","affiliation":[{"name":"Departments of aCell Biology,"},{"name":"Biochemistry, and"},{"name":"Genetics and Molecular Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Garshasbi","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; and"},{"name":"Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, 1985713834"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Kahrizi","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Gross","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano H.","family":"Apponi","sequence":"additional","affiliation":[{"name":"Pharmacology and Graduate Programs in"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Noto","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"},{"name":"Biochemistry, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara W.","family":"Leung","sequence":"additional","affiliation":[{"name":"Biochemistry, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Tzschach","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farkhondeh","family":"Behjati","sequence":"additional","affiliation":[{"name":"Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, 1985713834"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Sedigheh","family":"Abedini","sequence":"additional","affiliation":[{"name":"Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, 1985713834"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Mohseni","sequence":"additional","affiliation":[{"name":"Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, 1985713834"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars R.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Huang","sequence":"additional","affiliation":[{"name":"Genetics and Molecular Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara N.","family":"Stahley","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"},{"name":"Biochemistry, Cell, and Developmental Biology, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglu","family":"Liu","sequence":"additional","affiliation":[{"name":"Pharmacology and Graduate Programs in"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn R.","family":"Williams","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"},{"name":"Biochemistry, Cell, and Developmental Biology, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Burdick","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Feng","sequence":"additional","affiliation":[{"name":"Pharmacology and Graduate Programs in"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhabrata","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Bassell","sequence":"additional","affiliation":[{"name":"Departments of aCell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Hilger","family":"Ropers","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; 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