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These include selective reductions in total levels of dopamine- and cAMP-regulated phosphoprotein,\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>r<\/jats:sub>\n                    32 kDA (DARPP-32) and other dopamine-regulated phosphoprotein markers of medium spiny neurons. HD mice also show defects in dopamine-regulated ion channels and in the D\n                    <jats:sub>1<\/jats:sub>\n                    dopamine\/DARPP-32 signaling cascade. These presymptomatic defects may contribute to HD pathology.\n                  <\/jats:p>","DOI":"10.1073\/pnas.120166397","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:41:48Z","timestamp":1027680108000},"page":"6809-6814","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":235,"title":["Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice"],"prefix":"10.1073","volume":"97","author":[{"given":"James A.","family":"Bibb","sequence":"first","affiliation":[{"name":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021-6399; John B. 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