{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:43:47Z","timestamp":1779345827759,"version":"3.51.4"},"reference-count":37,"publisher":"Proceedings of the National Academy of Sciences","issue":"15","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,7,17]]},"abstract":"<jats:p>\n            The \u03b2 and proliferating cell nuclear antigen (PCNA) sliding clamps were first identified as components of their respective replicases, and thus were assigned a role in chromosome replication. Further studies have shown that the eukaryotic clamp, PCNA, interacts with several other proteins that are involved in excision repair, mismatch repair, cellular regulation, and DNA processing, indicating a much wider role than replication alone. Indeed, the\n            <jats:italic>Escherichia coli<\/jats:italic>\n            \u03b2 clamp is known to function with DNA polymerases II and V, indicating that \u03b2 also interacts with more than just the chromosomal replicase, DNA polymerase III. This report demonstrates three previously undetected protein\u2013protein interactions with the \u03b2 clamp. Thus, \u03b2 interacts with MutS, DNA ligase, and DNA polymerase I. Given the diverse use of these proteins in repair and other DNA transactions, this expanded list of \u03b2 interactive proteins suggests that the prokaryotic \u03b2 ring participates in a wide variety of reactions beyond its role in chromosomal replication.\n          <\/jats:p>","DOI":"10.1073\/pnas.121009498","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:34:10Z","timestamp":1027694050000},"page":"8376-8380","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":200,"title":["Interaction of the \u03b2 sliding clamp with MutS, ligase, and DNA polymerase I"],"prefix":"10.1073","volume":"98","author":[{"given":"Francisco J.","family":"L\u00f3pez de Saro","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute and The Rockefeller University, 1230 York Avenue, Box 228, New York, NY 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