{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:21:19Z","timestamp":1781896879013,"version":"3.54.5"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"12","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,6,11]]},"abstract":"<jats:p>\n                    Do endocannabinoids (eCBs) participate in long-term synaptic plasticity in the brain? Using pharmacological approaches and genetically altered mice, we show that stimulation of prelimbic cortex afferents at naturally occurring frequencies causes a long-term depression of nucleus accumbens glutamatergic synapses mediated by eCB release and presynaptic CB1 receptors. Translation of glutamate synaptic transmission into eCB retrograde signaling involved metabotropic glutamate receptors and postsynaptic intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores. These findings unveil the role of the eCB system in activity-dependent long-term synaptic plasticity and identify a mechanism by which marijuana can alter synaptic functions in the endogenous brain reward system.\n                  <\/jats:p>","DOI":"10.1073\/pnas.122149199","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:46:49Z","timestamp":1027680409000},"page":"8384-8388","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":491,"title":["Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens"],"prefix":"10.1073","volume":"99","author":[{"given":"David","family":"Robbe","sequence":"first","affiliation":[{"name":"Actions Concert\u00e9es Incitatives \u201cJeunes Chercheurs\u201d Plasticit\u00e9 Synaptique et Toxicomanie, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9023, 141 Rue de la Cardonille, 34094 Montpellier Cedex 05, France; Department of Environmental Sciences, Institute of Molecular Biomedicine, Swiss Federal Institute of Technology, 8044 Zurich, Switzerland; and Department of Molecular and Functional Genomics, Sanofi\u2013Synthelabo Recherche, Innopole, 31676 Lab\u00e8ge Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Kopf","sequence":"additional","affiliation":[{"name":"Actions Concert\u00e9es Incitatives \u201cJeunes Chercheurs\u201d Plasticit\u00e9 Synaptique et Toxicomanie, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9023, 141 Rue de la Cardonille, 34094 Montpellier Cedex 05, France; Department of Environmental Sciences, Institute of Molecular Biomedicine, Swiss Federal Institute of Technology, 8044 Zurich, Switzerland; and Department of Molecular and Functional Genomics, Sanofi\u2013Synthelabo Recherche, Innopole, 31676 Lab\u00e8ge Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Remaury","sequence":"additional","affiliation":[{"name":"Actions Concert\u00e9es Incitatives \u201cJeunes Chercheurs\u201d Plasticit\u00e9 Synaptique et Toxicomanie, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9023, 141 Rue de la Cardonille, 34094 Montpellier Cedex 05, France; Department of Environmental Sciences, Institute of Molecular Biomedicine, Swiss Federal Institute of Technology, 8044 Zurich, Switzerland; and Department of Molecular and Functional Genomics, Sanofi\u2013Synthelabo Recherche, Innopole, 31676 Lab\u00e8ge Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Bockaert","sequence":"additional","affiliation":[{"name":"Actions Concert\u00e9es Incitatives \u201cJeunes Chercheurs\u201d Plasticit\u00e9 Synaptique et Toxicomanie, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9023, 141 Rue de la Cardonille, 34094 Montpellier Cedex 05, France; Department of Environmental Sciences, Institute of Molecular Biomedicine, Swiss Federal Institute of Technology, 8044 Zurich, Switzerland; and Department of Molecular and Functional Genomics, Sanofi\u2013Synthelabo Recherche, Innopole, 31676 Lab\u00e8ge Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier J.","family":"Manzoni","sequence":"additional","affiliation":[{"name":"Actions Concert\u00e9es Incitatives \u201cJeunes Chercheurs\u201d Plasticit\u00e9 Synaptique et Toxicomanie, Centre National de la Recherche Scientifique, Unit\u00e9 Propre de Recherche 9023, 141 Rue de la Cardonille, 34094 Montpellier Cedex 05, France; Department of Environmental Sciences, Institute of Molecular Biomedicine, Swiss Federal Institute of Technology, 8044 Zurich, Switzerland; and Department of Molecular and Functional Genomics, Sanofi\u2013Synthelabo Recherche, Innopole, 31676 Lab\u00e8ge Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,6,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00087-2"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.38.1.179"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02470.2000"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.3.1286"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199803090-00020"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.867bj.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.6.3287"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.1.72"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-01-00109.2001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00247-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35069076"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-20-j0005.2001"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00200.2002"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00375-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00372-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00246-X"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5275.611"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80109-9"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01442-8"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2048"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01506.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-15-06629.1999"},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/B978-012442710-5\/50024-1","volume-title":"Immunology Methods Manual: The Comprehensive Sourcebook of Techniques","author":"Kopf M","year":"1996","unstructured":"M Kopf Immunology Methods Manual: The Comprehensive Sourcebook of Techniques, ed I Lefkovits (Academic, San Diego), pp. 199\u2013216 (1996)."},{"key":"e_1_3_3_24_2","first-page":"914","volume":"14","author":"Nitschke L","year":"1993","unstructured":"L Nitschke, M Kopf, M C Lamers Biotechniques 14, 914\u2013916 (1993).","journal-title":"Biotechniques"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.1127"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00218-9"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02217-4"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00719-2"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00174-5"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200004270-00018"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5329.1094"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00649-9"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)90025-6"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/7268"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90227-C"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00258-7"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.37.1.205"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01492-7"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-j0003.2001"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/42015"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.122149199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:19:43Z","timestamp":1649801983000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.122149199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,11]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2002,6,11]]}},"alternative-id":["10.1073\/pnas.122149199"],"URL":"https:\/\/doi.org\/10.1073\/pnas.122149199","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,11]]},"assertion":[{"value":"2002-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}